Rasagiline delays retinal degeneration in a mouse model of retinitis pigmentosa via modulation of Bax/Bcl-2 expression.

Ana B Garcia-DelgadoLourdes Valdés-SánchezSofia M CaladoFrancisco-Javier Díaz-CorralesShom S Bhattacharya

Published in: CNS neuroscience & therapeutics (2018)

This study provides new evidences regarding the neuroprotective effect of rasagiline in the retina, and it brings new insight into the development of future clinical trials using this well-established antiparkinsonian drug to treat RP.

Keyphrases

mouse model
clinical trial
diabetic retinopathy
poor prognosis
optical coherence tomography
optic nerve
current status
randomized controlled trial
emergency department
long non coding rna
phase ii
binding protein
signaling pathway
blood brain barrier
endoplasmic reticulum stress
study protocol
adverse drug