Genetic heterogeneity and tissue-specific patterns of tumors with multiple PIK3CA mutations.

Smruthy S Sivakumar Dexter X Jin Ruchita Rathod Jeffery S Ross Lewis C Cantley Maurizio Scaltriti Jessica W Chen Katherine E Hutchinson Timothy R Wilson Ethan S Sokol Neil Vasan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)

Our pan-tumor study provides biological insights into the genetic heterogeneity and tissue specificities of multi-PIK3CA mutations, with potential clinical utility to guide PI3K inhibition strategies.

Keyphrases

single cell
genome wide
copy number
protein kinase
dna methylation