Lewis C Cantley (Lewis Cantley)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 113

Top Venues

Nature

Science (New York, N.Y.)

Nature cancer

Science advances

Weill Cornell Medical College

Cornell University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Weill Cornell Medical College

United States

Director :: Sandra and Edward Meyer Cancer Center

Beth Israel Deaconess Medical Center

United States

Director :: Cancer Center

Harvard Medical School

United States

Professor :: Systems Biology

Beth Israel Deaconess Medical Center

United States

Division Chief :: Division of Signal Transduction /Dept. of Medicine

Harvard Medical School

United States

Professor :: Cell Biology

Tufts University School of Medicine

United States

Professor :: Physiology

Harvard University

United States

Associate Professor :: Biochemistry and Molecular Biology

Harvard University

United States

Assistant Professor :: Biochemistry and Molecular Biology

Education History

Cornell University

United States

PHD :: Biophysical Chemistry

West Virginia Wesleyan College

United States

BSC :: Chemistry

Publications

Eric E Gardner, Ethan M Earlie, Kate Li, Jerin Thomas, Melissa J Hubisz, Benjamin D Stein, Chen Zhang, Lewis C Cantley, Ashley M Laughney, Harold Varmus
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.) 383 (6683) (2024)
Tomer M Yaron, Brian A Joughin, Emily M Huntsman, Alexander Kerelsky, Daniel M Cizin, Benjamin M Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M Orozco, Christina Schoenherr, Cari Sagum, Mark T Bedford, R Max Wynn, Shih-Chia Tso, David T Chuang, Lei Li, Shawn Shun-Cheng Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean D Landry, Mohamed Uduman, John Blenis, Olivier Elemento, Margaret C Frame, Peter V Hornbeck, Lewis C Cantley, Benjamin E Turk, Micheal B Yaffe, Jared L Johnson
The intrinsic substrate specificity of the human tyrosine kinome. Nature (2024)
Sierra N Cullati, Kazutoshi Akizuki, Jun-Song Chen, Jared L Johnson, Tomer M Yaron, Lewis C Cantley, Kathleen L Gould
Substrate displacement of CK1 C-termini regulates kinase specificity. Science advances 10 (19) (2024)
Eric E Gardner, Ethan M Earlie, Kate Li, Jerin Thomas, Melissa J Hubisz, Benjamin D Stein, Chen Zhang, Lewis C Cantley, Ashley M Laughney, Harold Varmus
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.) 383 (6683) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer (2024)
Jennifer E Klomp, J Nathaniel Diehl, Jeffrey A Klomp, A Cole Edwards, Runying Yang, Alexis J Morales, Khalilah E Taylor, Kristina Drizyte-Miller, Kirsten L Bryant, Antje Schaefer, Jared L Johnson, Emily M Huntsman, Tomer M Yaron, Mariaelena Pierobon, Elisa Baldelli, Alex W Prevatte, Natalie K Barker, Laura E Herring, Emanuel F Petricoin, Lee M Graves, Lewis C Cantley, Adrienne D Cox, Channing J Der, Clint A Stalnecker
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer. Science (New York, N.Y.) 384 (6700) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer (2024)
Tomer M Yaron, Brian A Joughin, Emily M Huntsman, Alexander Kerelsky, Daniel M Cizin, Benjamin M Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M Orozco, Christina Schoenherr, Cari Sagum, Mark T Bedford, R Max Wynn, Shih-Chia Tso, David T Chuang, Lei Li, Shawn Shun-Cheng Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean D Landry, Mohamed Uduman, John Blenis, Olivier Elemento, Margaret C Frame, Peter V Hornbeck, Lewis C Cantley, Benjamin E Turk, Micheal B Yaffe, Jared L Johnson
The intrinsic substrate specificity of the human tyrosine kinome. Nature 629 (8014) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Evan K Noch, Laura Palma, Isaiah Yim, Nayah Bullen, Daniel Barnett, Alexander Walsh, Bhavneet Bhinder, Elisa Benedetti, Jan Krumsiek, Justin Gurvitch, Sumaiyah Khwaja, Daphne Atlas, Olivier Elemento, Lewis C Cantley
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production. Proceedings of the National Academy of Sciences of the United States of America 121 (8) (2024)
Luis A Diaz, Lewis C Cantley
Continuing the Conversation. Cancer discovery 14 (4) (2024)
Luis A Diaz, Lewis C Cantley
Continuing the Conversation. Cancer discovery 14 (4) (2024)
Eric E Gardner, Ethan M Earlie, Kate Li, Jerin Thomas, Melissa J Hubisz, Benjamin D Stein, Chen Zhang, Lewis C Cantley, Ashley M Laughney, Harold Varmus
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.) 383 (6683) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Jennifer E Klomp, J Nathaniel Diehl, Jeffrey A Klomp, A Cole Edwards, Runying Yang, Alexis J Morales, Khalilah E Taylor, Kristina Drizyte-Miller, Kirsten L Bryant, Antje Schaefer, Jared L Johnson, Emily M Huntsman, Tomer M Yaron, Mariaelena Pierobon, Elisa Baldelli, Alex W Prevatte, Natalie K Barker, Laura E Herring, Emanuel F Petricoin, Lee M Graves, Lewis C Cantley, Adrienne D Cox, Channing J Der, Clint A Stalnecker
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer. Science (New York, N.Y.) 384 (6700) (2024)
John R Ferrarone, Jerin Thomas, Arun M Unni, Yuxiang Zheng, Michal J Nagiec, Eric E Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano, Meer Mustafa, Lewis C Cantley, John Blenis, Neville E Sanjana, Harold Varmus
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Proceedings of the National Academy of Sciences of the United States of America 121 (21) (2024)
Jennifer E Klomp, J Nathaniel Diehl, Jeffrey A Klomp, A Cole Edwards, Runying Yang, Alexis J Morales, Khalilah E Taylor, Kristina Drizyte-Miller, Kirsten L Bryant, Antje Schaefer, Jared L Johnson, Emily M Huntsman, Tomer M Yaron, Mariaelena Pierobon, Elisa Baldelli, Alex W Prevatte, Natalie K Barker, Laura E Herring, Emanuel F Petricoin, Lee M Graves, Lewis C Cantley, Adrienne D Cox, Channing J Der, Clint A Stalnecker
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer. Science (New York, N.Y.) 384 (6700) (2024)
John R Ferrarone, Jerin Thomas, Arun M Unni, Yuxiang Zheng, Michal J Nagiec, Eric E Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano, Meer Mustafa, Lewis C Cantley, John Blenis, Neville E Sanjana, Harold Varmus
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Proceedings of the National Academy of Sciences of the United States of America 121 (21) (2024)
Evan K Noch, Laura Palma, Isaiah Yim, Nayah Bullen, Daniel Barnett, Alexander Walsh, Bhavneet Bhinder, Elisa Benedetti, Jan Krumsiek, Justin Gurvitch, Sumaiyah Khwaja, Daphne Atlas, Olivier Elemento, Lewis C Cantley
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production. Proceedings of the National Academy of Sciences of the United States of America 121 (8) (2024)
Evan K Noch, Laura Palma, Isaiah Yim, Nayah Bullen, Daniel Barnett, Alexander Walsh, Bhavneet Bhinder, Elisa Benedetti, Jan Krumsiek, Justin Gurvitch, Sumaiyah Khwaja, Daphne Atlas, Olivier Elemento, Lewis C Cantley
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production. Proceedings of the National Academy of Sciences of the United States of America 121 (8) (2024)
Evan K Noch, Laura Palma, Isaiah Yim, Nayah Bullen, Daniel Barnett, Alexander Walsh, Bhavneet Bhinder, Elisa Benedetti, Jan Krumsiek, Justin Gurvitch, Sumaiyah Khwaja, Daphne Atlas, Olivier Elemento, Lewis C Cantley
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production. Proceedings of the National Academy of Sciences of the United States of America 121 (8) (2024)
Eric E Gardner, Ethan M Earlie, Kate Li, Jerin Thomas, Melissa J Hubisz, Benjamin D Stein, Chen Zhang, Lewis C Cantley, Ashley M Laughney, Harold Varmus
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.) 383 (6683) (2024)
Eric E Gardner, Ethan M Earlie, Kate Li, Jerin Thomas, Melissa J Hubisz, Benjamin D Stein, Chen Zhang, Lewis C Cantley, Ashley M Laughney, Harold Varmus
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.) 383 (6683) (2024)
John R Ferrarone, Jerin Thomas, Arun M Unni, Yuxiang Zheng, Michal J Nagiec, Eric E Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano, Meer Mustafa, Lewis C Cantley, John Blenis, Neville E Sanjana, Harold Varmus
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Proceedings of the National Academy of Sciences of the United States of America 121 (21) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer (2024)
Tomer M Yaron, Brian A Joughin, Emily M Huntsman, Alexander Kerelsky, Daniel M Cizin, Benjamin M Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M Orozco, Christina Schoenherr, Cari Sagum, Mark T Bedford, R Max Wynn, Shih-Chia Tso, David T Chuang, Lei Li, Shawn Shun-Cheng Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean D Landry, Mohamed Uduman, John Blenis, Olivier Elemento, Margaret C Frame, Peter V Hornbeck, Lewis C Cantley, Benjamin E Turk, Micheal B Yaffe, Jared L Johnson
The intrinsic substrate specificity of the human tyrosine kinome. Nature 629 (8014) (2024)
Jennifer E Klomp, J Nathaniel Diehl, Jeffrey A Klomp, A Cole Edwards, Runying Yang, Alexis J Morales, Khalilah E Taylor, Kristina Drizyte-Miller, Kirsten L Bryant, Antje Schaefer, Jared L Johnson, Emily M Huntsman, Tomer M Yaron, Mariaelena Pierobon, Elisa Baldelli, Alex W Prevatte, Natalie K Barker, Laura E Herring, Emanuel F Petricoin, Lee M Graves, Lewis C Cantley, Adrienne D Cox, Channing J Der, Clint A Stalnecker
Determining the ERK-regulated phosphoproteome driving KRAS-mutant cancer. Science (New York, N.Y.) 384 (6700) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Yuling Han, Xiaohua Duan, Liuliu Yang, Benjamin E Nilsson-Payant, Pengfei Wang, Fuyu Duan, Xuming Tang, Tomer M Yaron, Tuo Zhang, Skyler Uhl, Yaron Bram, Chanel Richardson, Jiajun Zhu, Zeping Zhao, David Redmond, Sean Houghton, Duc-Huy T Nguyen, Dong Xu, Xing Wang, Jose Jessurun, Alain Borczuk, Yaoxing Huang, Jared L Johnson, Yuru Liu, Jenny Xiang, Hui Wang, Lewis C Cantley, Benjamin R tenOever, David D Ho, Fong Cheng Pan, Todd Evans, Huanhuan Joyce Chen, Robert E Schwartz, Shuibing Chen
Author Correction: Identification of SARS-CoV-2 inhibitors using lung and colonic organoids. Nature (2024)
Evan K Noch, Laura Palma, Isaiah Yim, Nayah Bullen, Daniel Barnett, Alexander Walsh, Bhavneet Bhinder, Elisa Benedetti, Jan Krumsiek, Justin Gurvitch, Sumaiyah Khwaja, Daphne Atlas, Olivier Elemento, Lewis C Cantley
Cysteine induces mitochondrial reductive stress in glioblastoma through hydrogen peroxide production. Proceedings of the National Academy of Sciences of the United States of America 121 (8) (2024)
Tomer M Yaron, Brian A Joughin, Emily M Huntsman, Alexander Kerelsky, Daniel M Cizin, Benjamin M Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M Orozco, Christina Schoenherr, Cari Sagum, Mark T Bedford, R Max Wynn, Shih-Chia Tso, David T Chuang, Lei Li, Shawn Shun-Cheng Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean D Landry, Mohamed Uduman, John Blenis, Olivier Elemento, Margaret C Frame, Peter V Hornbeck, Lewis C Cantley, Benjamin E Turk, Micheal B Yaffe, Jared L Johnson
The intrinsic substrate specificity of the human tyrosine kinome. Nature 629 (8014) (2024)
Sierra N Cullati, Kazutoshi Akizuki, Jun-Song Chen, Jared L Johnson, Tomer M Yaron, Lewis C Cantley, Kathleen L Gould
Substrate displacement of CK1 C-termini regulates kinase specificity. Science advances 10 (19) (2024)
Eric E Gardner, Ethan M Earlie, Kate Li, Jerin Thomas, Melissa J Hubisz, Benjamin D Stein, Chen Zhang, Lewis C Cantley, Ashley M Laughney, Harold Varmus
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.) 383 (6683) (2024)
Tomer M Yaron, Brian A Joughin, Emily M Huntsman, Alexander Kerelsky, Daniel M Cizin, Benjamin M Cohen, Amit Regev, Junho Song, Neil Vasan, Ting-Yu Lin, Jose M Orozco, Christina Schoenherr, Cari Sagum, Mark T Bedford, R Max Wynn, Shih-Chia Tso, David T Chuang, Lei Li, Shawn Shun-Cheng Li, Pau Creixell, Konstantin Krismer, Mina Takegami, Harin Lee, Bin Zhang, Jingyi Lu, Ian Cossentino, Sean D Landry, Mohamed Uduman, John Blenis, Olivier Elemento, Margaret C Frame, Peter V Hornbeck, Lewis C Cantley, Benjamin E Turk, Micheal B Yaffe, Jared L Johnson
The intrinsic substrate specificity of the human tyrosine kinome. Nature 629 (8014) (2024)
Eric E Gardner, Ethan M Earlie, Kate Li, Jerin Thomas, Melissa J Hubisz, Benjamin D Stein, Chen Zhang, Lewis C Cantley, Ashley M Laughney, Harold Varmus
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.) 383 (6683) (2024)
Sierra N Cullati, Kazutoshi Akizuki, Jun-Song Chen, Jared L Johnson, Tomer M Yaron, Lewis C Cantley, Kathleen L Gould
Substrate displacement of CK1 C-termini regulates kinase specificity. Science advances 10 (19) (2024)
Eric E Gardner, Ethan M Earlie, Kate Li, Jerin Thomas, Melissa J Hubisz, Benjamin D Stein, Chen Zhang, Lewis C Cantley, Ashley M Laughney, Harold Varmus
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.) 383 (6683) (2024)
Sierra N Cullati, Kazutoshi Akizuki, Jun-Song Chen, Jared L Johnson, Tomer M Yaron, Lewis C Cantley, Kathleen L Gould
Substrate displacement of CK1 C-termini regulates kinase specificity. Science advances 10 (19) (2024)
John R Ferrarone, Jerin Thomas, Arun M Unni, Yuxiang Zheng, Michal J Nagiec, Eric E Gardner, Oksana Mashadova, Kate Li, Nikos Koundouros, Antonino Montalbano, Meer Mustafa, Lewis C Cantley, John Blenis, Neville E Sanjana, Harold Varmus
Genome-wide CRISPR screens in spheroid culture reveal that the tumor suppressor LKB1 inhibits growth via the PIKFYVE lipid kinase. Proceedings of the National Academy of Sciences of the United States of America 121 (21) (2024)
Sierra N Cullati, Kazutoshi Akizuki, Jun-Song Chen, Jared L Johnson, Tomer M Yaron, Lewis C Cantley, Kathleen L Gould
Substrate displacement of CK1 C-termini regulates kinase specificity. Science advances 10 (19) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Meri Rogava, Tyler J Aprati, Wei-Yu Chi, Johannes C Melms, Clemens Hug, Stephanie H Davis, Ethan M Earlie, Charlie Chung, Sachin K Deshmukh, Sharon Wu, George Sledge, Stephen Tang, Patricia Ho, Amit Dipak Amin, Lindsay Caprio, Carino Gurjao, Somnath Tagore, Bryan Ngo, Michael J Lee, Giorgia Zanetti, Yiping Wang, Sean Chen, William Ge, Luiza Martins Nascentes Melo, Gabriele Allies, Jonas Rösler, Goeffrey T Gibney, Oliver J Schmitz, Megan Sykes, Rémi J Creusot, Thomas Tüting, Dirk Schadendorf, Martin Röcken, Thomas K Eigentler, Andrei Molotkov, Akiva Mintz, Samuel F Bakhoum, Semir Beyaz, Lewis C Cantley, Peter Karl Sorger, Sven W Meckelmann, Alpaslan Tasdogan, David R Liu, Ashley M Laughney, Benjamin Izar
Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature cancer 5 (3) (2024)
Eric E Gardner, Ethan M Earlie, Kate Li, Jerin Thomas, Melissa J Hubisz, Benjamin D Stein, Chen Zhang, Lewis C Cantley, Ashley M Laughney, Harold Varmus
Lineage-specific intolerance to oncogenic drivers restricts histological transformation. Science (New York, N.Y.) 383 (6683) (2024)
Joanna Triscott, Matthias Reist, Lukas Küng, Francielle C Moselle, Marika Lehner, John Gallon, Archna Ravi, Gurpreet K Arora, Simone de Brot, Mark Lundquist, Hector Gallart-Ayala, Julijana Ivanisevic, Salvatore Piscuoglio, Lewis C Cantley, Brooke M Emerling, Mark A Rubin
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition. Science advances 9 (5) (2023)
Narek Darabedian, Wenzhi Ji, Mengyang Fan, Shan Lin, Hyuk-Soo Seo, Ekaterina V Vinogradova, Tomer M Yaron, Evanna L Mills, Haopeng Xiao, Kristine Senkane, Emily M Huntsman, Jared L Johnson, Jianwei Che, Lewis C Cantley, Benjamin F Cravatt, Sirano Dhe-Paganon, Kimberly Stegmaier, Tinghu Zhang, Nathanael S Gray, Edward T Chouchani
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor. Nature chemical biology (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Priya Bhardwaj, Neil M Iyengar, Heba M Zahid, Katharine M Carter, Dong Jun Byun, Man Ho Choi, Qi Sun, Oleksandr Savenkov, Charalambia Louka, Catherine Liu, Phoebe Piloco, Monica Acosta, Rohan Bareja, Olivier Elemento, Miguel Foronda, Lukas E Dow, Sofya Oshchepkova, Dilip D Giri, Michael N Pollak, Xi Kathy Zhou, Benjamin D Hopkins, Ashley M Laughney, Melissa K Frey, Lora Hedrick Ellenson, Monica Morrow, Jason A Spector, Lewis C Cantley, Kristy A Brown
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2 . Science translational medicine 15 (684) (2023)
Smruthy S Sivakumar, Dexter X Jin, Ruchita Rathod, Jeffery S Ross, Lewis C Cantley, Maurizio Scaltriti, Jessica W Chen, Katherine E Hutchinson, Timothy R Wilson, Ethan S Sokol, Neil Vasan
Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Priya Bhardwaj, Neil M Iyengar, Heba M Zahid, Katharine M Carter, Dong Jun Byun, Man Ho Choi, Qi Sun, Oleksandr Savenkov, Charalambia Louka, Catherine Liu, Phoebe Piloco, Monica Acosta, Rohan Bareja, Olivier Elemento, Miguel Foronda, Lukas E Dow, Sofya Oshchepkova, Dilip D Giri, Michael N Pollak, Xi Kathy Zhou, Benjamin D Hopkins, Ashley M Laughney, Melissa K Frey, Lora Hedrick Ellenson, Monica Morrow, Jason A Spector, Lewis C Cantley, Kristy A Brown
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2 . Science translational medicine 15 (684) (2023)
Narek Darabedian, Wenzhi Ji, Mengyang Fan, Shan Lin, Hyuk-Soo Seo, Ekaterina V Vinogradova, Tomer M Yaron, Evanna L Mills, Haopeng Xiao, Kristine Senkane, Emily M Huntsman, Jared L Johnson, Jianwei Che, Lewis C Cantley, Benjamin F Cravatt, Sirano Dhe-Paganon, Kimberly Stegmaier, Tinghu Zhang, Nathanael S Gray, Edward T Chouchani
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor. Nature chemical biology (2023)
Amina Jbara, Kuan-Ting Lin, Chani Stossel, Zahava Siegfried, Haya Shqerat, Adi Amar-Schwartz, Ela Elyada, Maxim Mogilevsky, Maria Raitses-Gurevich, Jared L Johnson, Tomer M Yaron, Ofek Ovadia, Gun Ho Jang, Miri Danan Gotthold, Lewis C Cantley, Erez Y Levanon, Steven Gallinger, Adrian R Krainer, Talia Golan, Rotem Karni
RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Nature (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Joanna Triscott, Matthias Reist, Lukas Küng, Francielle C Moselle, Marika Lehner, John Gallon, Archna Ravi, Gurpreet K Arora, Simone de Brot, Mark Lundquist, Hector Gallart-Ayala, Julijana Ivanisevic, Salvatore Piscuoglio, Lewis C Cantley, Brooke M Emerling, Mark A Rubin
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition. Science advances 9 (5) (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Joanna Triscott, Matthias Reist, Lukas Küng, Francielle C Moselle, Marika Lehner, John Gallon, Archna Ravi, Gurpreet K Arora, Simone de Brot, Mark Lundquist, Hector Gallart-Ayala, Julijana Ivanisevic, Salvatore Piscuoglio, Lewis C Cantley, Brooke M Emerling, Mark A Rubin
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition. Science advances 9 (5) (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Smruthy S Sivakumar, Dexter X Jin, Ruchita Rathod, Jeffery S Ross, Lewis C Cantley, Maurizio Scaltriti, Jessica W Chen, Katherine E Hutchinson, Timothy R Wilson, Ethan S Sokol, Neil Vasan
Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Joanna Triscott, Matthias Reist, Lukas Küng, Francielle C Moselle, Marika Lehner, John Gallon, Archna Ravi, Gurpreet K Arora, Simone de Brot, Mark Lundquist, Hector Gallart-Ayala, Julijana Ivanisevic, Salvatore Piscuoglio, Lewis C Cantley, Brooke M Emerling, Mark A Rubin
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition. Science advances 9 (5) (2023)
Swagatika Paul, Shireen A Sarraf, Ki Hong Nam, Leila Zavar, Nicole DeFoor, Sahitya Ranjan Biswas, Lauren E Fritsch, Tomer M Yaron, Jared L Johnson, Emily M Huntsman, Lewis C Cantley, Alban Ordureau, Alicia M Pickrell
NAK-associated protein 1/NAP1 activates TBK1 to ensure accurate mitosis and cytokinesis. The Journal of cell biology 223 (2) (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Smruthy S Sivakumar, Dexter X Jin, Ruchita Rathod, Jeffery S Ross, Lewis C Cantley, Maurizio Scaltriti, Jessica W Chen, Katherine E Hutchinson, Timothy R Wilson, Ethan S Sokol, Neil Vasan
Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Joanna Triscott, Matthias Reist, Lukas Küng, Francielle C Moselle, Marika Lehner, John Gallon, Archna Ravi, Gurpreet K Arora, Simone de Brot, Mark Lundquist, Hector Gallart-Ayala, Julijana Ivanisevic, Salvatore Piscuoglio, Lewis C Cantley, Brooke M Emerling, Mark A Rubin
PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition. Science advances 9 (5) (2023)
Smruthy S Sivakumar, Dexter X Jin, Ruchita Rathod, Jeffery S Ross, Lewis C Cantley, Maurizio Scaltriti, Jessica W Chen, Katherine E Hutchinson, Timothy R Wilson, Ethan S Sokol, Neil Vasan
Genetic Heterogeneity and Tissue-specific Patterns of Tumors with Multiple PIK3CA Mutations. Clinical cancer research : an official journal of the American Association for Cancer Research 29 (6) (2023)
Priya Bhardwaj, Neil M Iyengar, Heba M Zahid, Katharine M Carter, Dong Jun Byun, Man Ho Choi, Qi Sun, Oleksandr Savenkov, Charalambia Louka, Catherine Liu, Phoebe Piloco, Monica Acosta, Rohan Bareja, Olivier Elemento, Miguel Foronda, Lukas E Dow, Sofya Oshchepkova, Dilip D Giri, Michael N Pollak, Xi Kathy Zhou, Benjamin D Hopkins, Ashley M Laughney, Melissa K Frey, Lora Hedrick Ellenson, Monica Morrow, Jason A Spector, Lewis C Cantley, Kristy A Brown
Obesity promotes breast epithelium DNA damage in women carrying a germline mutation in BRCA1 or BRCA2 . Science translational medicine 15 (684) (2023)
Smruthy S Sivakumar, Dexter X Jin, Ruchita Rathod, Jeffery S Ross, Lewis C Cantley, Maurizio Scaltriti, Jessica W Chen, Katherine E Hutchinson, Timothy R Wilson, Ethan S Sokol, Neil Vasan
Genetic heterogeneity and tissue-specific patterns of tumors with multiple PIK3CA mutations. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Benjamin D Stein, John R Ferrarone, Eric E Gardner, Jae Won Chang, David Wu, Pablo E Hollstein, Roger J Liang, Min Yuan, Qiuying Chen, John S Coukos, Miriam Sindelar, Bryan Ngo, Steven S Gross, Reuben J Shaw, Chen Zhang, John M Asara, Raymond E Moellering, Harold Varmus, Lewis C Cantley
LKB1-dependent regulation of TPI1 creates a divergent metabolic liability between human and mouse lung adenocarcinoma. Cancer discovery (2023)
Fahrettin Haczeyni, Sandra Steensels, Benjamin D Stein, James M Jordan, Le Li, Vincent Dartigue, Selenay S Sarklioglu, Jixuan Qiao, Xi K Zhou, Andrew J Dannenberg, Neil M Iyengar, Haiyuan Yu, Lewis C Cantley, Baran A Ersoy
Submitochondrial Protein Translocation Upon Stress Inhibits Thermogenic Energy Expenditure. bioRxiv : the preprint server for biology (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature 613 (7945) (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature (2023)
Luis A Diaz, Lewis C Cantley
The Hallmarks of a Cancer Discovery. Cancer discovery 13 (4) (2023)
Jared L Johnson, Tomer M Yaron, Emily M Huntsman, Alexander Kerelsky, Junho Song, Amit Regev, Ting-Yu Lin, Katarina Liberatore, Daniel M Cizin, Benjamin M Cohen, Neil Vasan, Yilun Ma, Konstantin Krismer, Jaylissa Torres Robles, Bert van de Kooij, Anne E van Vlimmeren, Nicole Andrée-Busch, Norbert F Käufer, Maxim V Dorovkov, Alexey G Ryazanov, Yuichiro Takagi, Edward R Kastenhuber, Marcus DaSilva Goncalves, Benjamin D Hopkins, Olivier Elemento, Dylan J Taatjes, Alexandre Maucuer, Akio Yamashita, Alexei Degterev, Mohamed Uduman, Jingyi Lu, Sean D Landry, Bin Zhang, Ian Cossentino, Rune Linding, John Blenis, Peter V Hornbeck, Benjamin E Turk, Micheal B Yaffe, Lewis C Cantley
An atlas of substrate specificities for the human serine/threonine kinome. Nature (2023)
Fahrettin Haczeyni, Sandra Steensels, Benjamin D Stein, James M Jordan, Le Li, Vincent Dartigue, Selenay S Sarklioglu, Jixuan Qiao, Xi K Zhou, Andrew J Dannenberg, Neil M Iyengar, Haiyuan Yu, Lewis C Cantley, Baran A Ersoy
Submitochondrial Protein Translocation Upon Stress Inhibits Thermogenic Energy Expenditure. bioRxiv : the preprint server for biology (2023)
Samuel R Taylor, John N Falcone, Lewis C Cantley, Marcus DaSilva Goncalves
Developing dietary interventions as therapy for cancer. Nature reviews. Cancer 22 (8) (2022)
Kenneth C Anderson, Lewis C Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A Diaz, Raymond N DuBois, Keith T Flaherty, Philip D Greenberg, Massimo Loda, Elaine R Mardis, Elizabeth A Platz, Michael N Pollak, Robert D Schreiber, Lillian L Siu, Beverly A Teicher
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Molecular cancer therapeutics 21 (11) (2022)
Kenneth C Anderson, Lewis C Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A Diaz, Raymond N DuBois, Keith T Flaherty, Philip D Greenberg, Massimo Loda, Elaine R Mardis, Elizabeth A Platz, Michael N Pollak, Robert D Schreiber, Lillian L Siu, Beverly A Teicher
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Molecular cancer research : MCR 20 (11) (2022)
Kenneth C Anderson, Lewis C Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A Diaz, Raymond N DuBois, Keith T Flaherty, Philip D Greenberg, Massimo Loda, Elaine R Mardis, Elizabeth A Platz, Michael N Pollak, Robert D Schreiber, Lillian L Siu, Beverly A Teicher
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (21) (2022)
Felipe Batalini, Niya Xiong, Nabihah Tayob, Madeline Polak, Julia Eismann, Lewis C Cantley, Geoffrey I Shapiro, Viktor Adalsteinsson, Eric P Winer, Panagiotis A Konstantinopoulos, Alan D' Andrea, Elizabeth M Swisher, Ursula A Matulonis, Gerburg M Wulf, Erica L Mayer
Phase 1b Clinical Trial with Alpelisib plus Olaparib for Patients with Advanced Triple-Negative Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (8) (2022)
Kenneth C Anderson, Lewis C Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A Diaz, Raymond N DuBois, Keith T Flaherty, Philip D Greenberg, Massimo Loda, Elaine R Mardis, Elizabeth A Platz, Michael N Pollak, Robert D Schreiber, Lillian L Siu, Beverly A Teicher
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer discovery 12 (11) (2022)
Tomer M Yaron, Brook E Heaton, Tyler M Levy, Jared L Johnson, Tristan X Jordan, Benjamin M Cohen, Alexander Kerelsky, Ting-Yu Lin, Katarina M Liberatore, Danielle K Bulaon, Samantha J Van Nest, Nikos Koundouros, Edward R Kastenhuber, Marisa N Mercadante, Kripa Shobana-Ganesh, Long He, Robert E Schwartz, Shuibing Chen, Harel Weinstein, Olivier Elemento, Elena Piskounova, Benjamin E Nilsson-Payant, Gina Lee, Joseph D Trimarco, Kaitlyn N Burke, Cait E Hamele, Ryan R Chaparian, Alfred T Harding, Aleksandra Tata, Xinyu Zhu, Purushothama Rao Tata, Clare M Smith, Anthony P Possemato, Sasha L Tkachev, Peter V Hornbeck, Sean A Beausoleil, Shankara K Anand, François Aguet, Gad A Getz, Andrew D Davidson, Kate J Heesom, Maia Kavanagh Williamson, David A Matthews, Benjamin R tenOever, Lewis C Cantley, John Blenis, Nicholas S Heaton
Host protein kinases required for SARS-CoV-2 nucleocapsid phosphorylation and viral replication. Science signaling 15 (757) (2022)
Kenneth C Anderson, Lewis C Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A Diaz, Raymond N DuBois, Keith T Flaherty, Philip D Greenberg, Massimo Loda, Elaine R Mardis, Elizabeth A Platz, Michael N Pollak, Robert D Schreiber, Lillian L Siu, Beverly A Teicher
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Blood cancer discovery 3 (6) (2022)
Christian C Dibble, Samuel A Barritt, Grace E Perry, Evan C Lien, Renee C Geck, Sarah E DuBois-Coyne, David Bartee, Thomas T Zengeya, Emily B Cohen, Min Yuan, Benjamin D Hopkins, Jordan L Meier, John Gerard Clohessy, John M Asara, Lewis C Cantley, Alex Toker
PI3K drives the de novo synthesis of coenzyme A from vitamin B5. Nature 608 (7921) (2022)
Shawn M Davidson, Daniel R Schmidt, Julia E Heyman, James P O'Brien, Amy C Liu, William J Israelsen, Talya L Dayton, Raghav Sehgal, Roderick T Bronson, Elizaveta Freinkman, Howard H Mak, Giuseppe Nicolò Fanelli, Scott Malstrom, Gary Bellinger, Arkaitz Carracedo, Pier Paolo Pandolfi, Kevin Dale Courtney, Abhishek Jha, Ronald A DePinho, James W Horner, Craig J Thomas, Lewis C Cantley, Massimo Loda, Matthew G Vander Heiden
Pyruvate Kinase M1 Suppresses Development and Progression of Prostate Adenocarcinoma. Cancer research 82 (13) (2022)
Zhongchi Li, Vivien Low, Valbona Luga, Janet Sun, Ethan Earlie, Bobak Parang, Kripa Shobana Ganesh, Sungyun Cho, Jennifer Endress, Tanya Schild, Mengying Hu, David C Lyden, Wenbing Jin, Chunjun Guo, Noah Dephoure, Lewis C Cantley, Ashley M Laughney, John Blenis
Tumor-produced and aging-associated oncometabolite methylmalonic acid promotes cancer-associated fibroblast activation to drive metastatic progression. Nature communications 13 (1) (2022)
Neil Vasan, Lewis C Cantley
At a crossroads: how to translate the roles of PI3K in oncogenic and metabolic signalling into improvements in cancer therapy. Nature reviews. Clinical oncology 19 (7) (2022)
Kenneth C Anderson, Lewis C Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A Diaz, Raymond N DuBois, Keith T Flaherty, Philip D Greenberg, Massimo Loda, Elaine R Mardis, Elizabeth A Platz, Michael N Pollak, Robert D Schreiber, Lillian L Siu, Beverly A Teicher
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer prevention research (Philadelphia, Pa.) 15 (11) (2022)
Kenneth C Anderson, Lewis C Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A Diaz, Raymond N DuBois, Keith T Flaherty, Philip D Greenberg, Massimo Loda, Elaine R Mardis, Elizabeth A Platz, Michael N Pollak, Robert D Schreiber, Lillian L Siu, Beverly A Teicher
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer research 82 (21) (2022)
Ana P Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B Nunes, Bethany E Schaffer, Anders P Mutvei, John M Asara, Lewis C Cantley, Sarah-Maria Fendt, John Blenis
Altered propionate metabolism contributes to tumour progression and aggressiveness. Nature metabolism 4 (4) (2022)
Andre Lima Queiroz, Ezequiel Dantas, Shakti Ramsamooj, Anirudh Murthy, Mujmmail Ahmed, Elizabeth R M Zunica, Roger J Liang, Jessica Murphy, Corey D Holman, Curtis J Bare, Gregory C Ghahramani, Zhidan Wu, David E Cohen, John P Kirwan, Lewis C Cantley, Christopher L Axelrod, Marcus DaSilva Goncalves
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer. Nature communications 13 (1) (2022)
Kenneth C Anderson, Lewis C Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A Diaz, Raymond N DuBois, Keith T Flaherty, Philip D Greenberg, Massimo Loda, Elaine R Mardis, Elizabeth A Platz, Michael N Pollak, Robert D Schreiber, Lillian L Siu, Beverly A Teicher
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 31 (11) (2022)
Edward R Kastenhuber, Marisa Mercadante, Benjamin Nilsson-Payant, Jared L Johnson, Javier A Jaimes, Frauke Mücksch, Yiska Weisblum, Yaron Bram, Vasuretha Chandar, Gary R Whittaker, Benjamin R tenOever, Robert E Schwartz, Lewis C Cantley
Coagulation factors directly cleave SARS-CoV-2 spike and enhance viral entry. eLife 11 (2022)
Kenneth C Anderson, Lewis C Cantley, Riccardo Dalla-Favera, Chi Van Dang, Luis A Diaz, Raymond N DuBois, Keith T Flaherty, Philip D Greenberg, Massimo Loda, Elaine R Mardis, Elizabeth A Platz, Michael N Pollak, Robert D Schreiber, Lillian L Siu, Beverly A Teicher
The AACR Journals: Advancing Progress Toward the AACR's 115-Year Mission. Cancer immunology research 10 (11) (2022)
Samuel R Taylor, Shakti Ramsamooj, Roger J Liang, Alyna Katti, Rita Pozovskiy, Neil Vasan, Seo-Kyoung Hwang, Navid Nahiyaan, Nancy J Francoeur, Emma M Schatoff, Jared L Johnson, Manish A Shah, Andrew J Dannenberg, Robert P Sebra, Lukas E Dow, Lewis C Cantley, Kyu Y Rhee, Marcus DaSilva Goncalves
Dietary fructose improves intestinal cell survival and nutrient absorption. Nature 597 (7875) (2021)
Luis A Diaz, Lewis C Cantley
A Decade of Cancer Discovery. Cancer discovery 11 (4) (2021)

Lewis C Cantley.css-eqlu8i{font-size:small;padding-left:4px;} (Lewis Cantley)

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Lewis C Cantley (Lewis Cantley)