Hepatocyte growth factor (HGF) and stem cell factor (SCF) maintained the stemness of human bone marrow mesenchymal stem cells (hBMSCs) during long-term expansion by preserving mitochondrial function via the PI3K/AKT, ERK1/2, and STAT3 signaling pathways.
Zeyuan CaoYunyi XieLe YuYi LiYan WangPublished in: Stem cell research & therapy (2020)
Both HGF and SCF are key factors in maintaining the stemness of hBMSCs by preserving mitochondrial function through the expression of proteins associated with the PI3K/AKT, ERK1/2, and STAT3 signaling pathways. This study provides new insights into the anti-senescence capability of HGF and SCF, as well as new evidence for their potential application in optimizing the long-term culture of MSCs.
Keyphrases
- signaling pathway
- stem cells
- growth factor
- epithelial mesenchymal transition
- pi k akt
- cell proliferation
- endothelial cells
- induced apoptosis
- poor prognosis
- dna damage
- pluripotent stem cells
- long non coding rna
- stress induced
- cancer stem cells
- induced pluripotent stem cells
- oxidative stress
- climate change
- human health