TARGIT-R (Retrospective): 5-Year Follow-Up Evaluation of Intraoperative Radiation Therapy (IORT) for Breast Cancer Performed in North America.
Stephanie A ValenteRahul D TendulkarSheen CherianChirag ShahDarrel L RossS Chace LottichChristine LarongaKristy K BromanEric D DonnellyKevin P BethkeChristina ShawNatalie A LockneyAaron PedersonRay RudolphMichael HassellePond KelemenUlrich HermantoAndrew AshikariSong KangRichard A HoeferDavid McCreadyAnthony FylesJamie EscallonNitin RohatgiJeannine GravesGregory GravesShawna C WilleyEleni TousimisLee RileyNimisha DebChao TuWilliam SmallStephen R GrobmyerPublished in: Annals of surgical oncology (2021)
The local recurrence rates in this series differ slightly from recent results of randomized IORT trials and are notably higher than in previous published studies using whole-breast radiotherapy for similar patients with early-stage breast cancer. Understanding differences in this retrospective series and the prospective trials will be critical to optimizing patient selection and outcomes going forward.