Ex vivo study of IL-6 expression and function in immune cell subsets from human periapical lesions.

Tanja Milan Dzopalic Sergej Tomić Marina Bekić Dragana Vučević Dušan Mihajlović Mile Eraković Miodrag Čolić

Published in: International endodontic journal (2022)

Most immune cells from Sy PLs expressed higher levels of IL-6 compared with Asy PLs, which correlated with IL-6 production in culture. Analysis of cytokines suggested a dominant pro-inflammatory T-cell response and osteodestructive function of IL-6 in PLs judging by Th17/Tfh cell activation, Tregs inhibition and increased RANKL/OPG ratio. Excessive IL-6 production decreased Th1/Th2 responses.

Keyphrases

endothelial cells
poor prognosis
single cell
stem cells
immune response
inflammatory response
body mass index
peripheral blood
bone marrow
weight loss
physical activity
cell therapy
toll like receptor
induced pluripotent stem cells
pluripotent stem cells