Ex vivo study of IL-6 expression and function in immune cell subsets from human periapical lesions.
Tanja Milan DzopalicSergej TomićMarina BekićDragana VučevićDušan MihajlovićMile ErakovićMiodrag ČolićPublished in: International endodontic journal (2022)
Most immune cells from Sy PLs expressed higher levels of IL-6 compared with Asy PLs, which correlated with IL-6 production in culture. Analysis of cytokines suggested a dominant pro-inflammatory T-cell response and osteodestructive function of IL-6 in PLs judging by Th17/Tfh cell activation, Tregs inhibition and increased RANKL/OPG ratio. Excessive IL-6 production decreased Th1/Th2 responses.