HIF-1α-mediated LAMC1 overexpression is an unfavorable predictor of prognosis for glioma patients: evidence from pan-cancer analysis and validation experiments.
Jianrong BaiYangyang ZhaoKaijia ShiYonghao FanYanping HaYan ChenBotao LuoYanda LuWei JieZhihua ShenPublished in: Journal of translational medicine (2024)
High expression of LAMC1 in some solid tumors including gliomas suggests a poor prognosis. The hypoxic microenvironment in gliomas activates the HIF-1α/LAMC1 signaling, thereby promoting tumor progression. Targeted intervention on the HIF-1α/LAMC1 signaling attenuates cell growth and invasion, suggesting a new strategy for glioma treatment.
Keyphrases
- poor prognosis
- long non coding rna
- end stage renal disease
- high grade
- endothelial cells
- randomized controlled trial
- ejection fraction
- chronic kidney disease
- stem cells
- cell proliferation
- peritoneal dialysis
- prognostic factors
- transcription factor
- squamous cell carcinoma
- cancer therapy
- cell migration
- clinical evaluation