Myocardial Metabolomics of Human Heart Failure With Preserved Ejection Fraction.
Virginia S HahnChristopher PetucciMin-Soo KimKenneth C BediHanghang WangSumita MishraSaeid GhavamiReynold A PanettieriKenneth B MarguliesZoltan AranyDaniel P KellyDavid A KassKavita SharmaPublished in: Circulation (2023)
Despite marked obesity and diabetes, HFpEF myocardium exhibited lower fatty acid metabolites compared with HFrEF. Ketones and metabolites of the tricarboxylic acid cycle and BCAA were also lower in HFpEF, suggesting insufficient use of alternative fuels. These differences were not detectable in plasma and challenge conventional views of myocardial fuel use in HFpEF with marked diabetes and obesity and suggest substantial fuel inflexibility in this syndrome.
Keyphrases
- type diabetes
- insulin resistance
- weight loss
- metabolic syndrome
- glycemic control
- ms ms
- fatty acid
- cardiovascular disease
- left ventricular
- high fat diet induced
- weight gain
- endothelial cells
- mass spectrometry
- induced pluripotent stem cells
- adipose tissue
- skeletal muscle
- heart failure
- case report
- pluripotent stem cells