One-Year Effects of High-Intensity Statin on Bioactive Lipids: Findings From the JUPITER Trial.

Rosangela Akemi Hoshi Mona AlotaibiYanyan LiuJeramie D WatrousPaul M Ridker Robert J Glynn Charles Nicholas Serhan Heike Luttmann-GibsonM Vinayaga MoorthyMohit JainDemler V Olga Samia Mora

Published in: Arteriosclerosis, thrombosis, and vascular biology (2024)

Statin allocation was significantly associated with upregulation of BALs with anti-inflammatory, antiplatelet aggregation and antioxidant properties and downregulation of BALs with proinflammatory and proplatelet aggregation activity, supporting the pleiotropic effects of statins beyond low-density lipoprotein cholesterol reduction.

Keyphrases

high intensity
anti inflammatory
cardiovascular disease
cell proliferation
resistance training
coronary artery disease
signaling pathway
study protocol
phase iii
clinical trial
low density lipoprotein
poor prognosis
oxidative stress
open label