Advances in diet-induced rodent models of metabolically acquired peripheral neuropathy.
Stephanie A EidEva L FeldmanPublished in: Disease models & mechanisms (2021)
Peripheral neuropathy (PN) is a severe complication that affects over 30% of prediabetic and 60% of type 2 diabetic (T2D) patients. The metabolic syndrome is increasingly recognized as a major driver of PN. However, basic and translational research is needed to understand the mechanisms that contribute to nerve damage. Rodent models of diet-induced obesity, prediabetes, T2D and PN closely resemble the human disease and have proven to be instrumental for the study of PN mechanisms. In this Perspective article, we focus on the development, neurological characterization and dietary fat considerations of diet-induced rodent models of PN. We highlight the importance of investigating sex differences and discuss some of the challenges in translation from bench to bedside, including recapitulating the progressive nature of human PN and modeling neuropathic pain. We emphasize that future research should overcome these challenges in the quest to better mimic human PN in animal models.
Keyphrases
- endothelial cells
- metabolic syndrome
- neuropathic pain
- end stage renal disease
- induced pluripotent stem cells
- insulin resistance
- spinal cord injury
- pluripotent stem cells
- multiple sclerosis
- spinal cord
- newly diagnosed
- chronic kidney disease
- adipose tissue
- weight loss
- ejection fraction
- peritoneal dialysis
- physical activity
- cardiovascular disease
- fatty acid
- body mass index
- brain injury
- skeletal muscle
- cardiovascular risk factors
- drug induced