Kinetic characteristics of propofol-induced inhibition of electron-transfer chain and fatty acid oxidation in human and rodent skeletal and cardiac muscles.
Tomáš UrbanPetr WaldaufAdéla KrajčováKateřina JiroutkováMilada HalačováValér DžupaLibor JanoušekEva PokornáFrantišek DuškaPublished in: PloS one (2019)
In human skeletal and heart muscle homogenates, propofol in concentrations that are achieved in propofol-anaesthetized patients, causes a direct inhibition of fatty acid oxidation, in addition to inhibiting flux of electrons through inner mitochondrial membrane. The inhibition is more marked in human as compared to rodent tissues.
Keyphrases
- endothelial cells
- fatty acid
- electron transfer
- induced pluripotent stem cells
- pluripotent stem cells
- end stage renal disease
- heart failure
- gene expression
- hydrogen peroxide
- ejection fraction
- oxidative stress
- signaling pathway
- chronic kidney disease
- left ventricular
- prognostic factors
- nitric oxide
- diabetic rats
- patient reported outcomes