Transcranial photobiomodulation (PBM) also known as low level laser therapy (tLLLT) relies on the use of red/NIR light to stimulate, preserve and regenerate cells and tissues. The mechanism of action involves photon absorption in the mitochondria (cytochrome c oxidase), and ion channels in cells leading to activation of signaling pathways, up-regulation of transcription factors, and increased expression of protective genes. We have studied PBM for treating traumatic brain injury (TBI) in mice using a NIR laser spot delivered to the head. Mice had improved memory and learning, increased neuroprogenitor cells in the dentate gyrus and subventricular zone, increased BDNF and more synaptogenesis in the cortex. These highly beneficial effects on the brain suggest that the applications of tLLLT are much broader than at first conceived. Other groups have studied stroke (animal models and clinical trials), Alzheimer's disease, Parkinson's disease, depression, and cognitive enhancement in healthy subjects.
Keyphrases
- induced apoptosis
- traumatic brain injury
- cell cycle arrest
- clinical trial
- signaling pathway
- transcription factor
- endoplasmic reticulum stress
- cell death
- gene expression
- white matter
- oxidative stress
- photodynamic therapy
- randomized controlled trial
- type diabetes
- drug delivery
- cerebral ischemia
- cell proliferation
- study protocol
- high fat diet induced
- subarachnoid hemorrhage
- optical coherence tomography
- open label
- stress induced
- sleep quality
- cerebral blood flow
- mild traumatic brain injury