Low-Dose TMP-SMX in the Treatment of Pneumocystis jirovecii Pneumonia: A Systematic Review and Meta-analysis.

Guillaume Butler-LaporteElizabeth SmythAlexandre Amar-ZifkinMatthew Pellan ChengEmily G McDonaldTodd C Lee

Published in: Open forum infectious diseases (2020)

In this systematic review, treatment of PJP with doses of ≤10 mg/kg/d of trimethoprim was associated with similar rates of mortality when compared with standard doses and with significantly fewer treatment-emergent severe adverse events. Although limited by the observational nature of the studies included, this review provides the most current available evidence for the optimal dosing of TMP-SMX in the treatment of PJP.

Keyphrases

systematic review
low dose
randomized controlled trial
cardiovascular disease
intensive care unit
combination therapy
early onset
replacement therapy
risk factors
cross sectional
meta analyses