KLRG1 is reduced on NK cells in SLE patients, inversely correlates with disease activity and is modulated by hydroxychloroquine in vitro .

Lucia NovelliCristiana BarbatiCristina CapuanoSerena RecalchiFulvia CeccarelliMarta VomeroCristiano AlessandriStefania MorroneFabrizio Conti

Published in: Lupus (2023)

With this study we revealed a reduced expression and an impaired function of KLRG1 on NK cells in SLE patients. These results suggest a possible role of KLRG1 in the pathogenesis of SLE and as a novel biomarker of this disease.

Keyphrases

disease activity
systemic lupus erythematosus
end stage renal disease
nk cells
rheumatoid arthritis
ejection fraction
newly diagnosed
chronic kidney disease
rheumatoid arthritis patients
peritoneal dialysis
prognostic factors
ankylosing spondylitis
poor prognosis
patient reported outcomes