Increased expression of the ATP-gated P2X7 receptor reduces responsiveness to anti-convulsants during status epilepticus in mice.
Edward BeamerJames MorganMariana AlvesAida Menéndez MéndezGareth MorrisBéla ZimmerGiorgia ConteLaura de Diego-GarciaCristina Alarcón-VilaNico Ka Yiu NgStephen MaddenFrancesco CalzaferriCristóbal de Los RíosAntonio G GarcíaMichael HamacherKlaus DinkelPablo PelegrinDavid C HenshallAnnette NickeTobias Engel Ayer BotrelPublished in: British journal of pharmacology (2022)
Our results demonstrate that P2X7 receptor-induced pro-inflammatory effects contribute to resistance to pharmacotherapy during status epilepticus. Therapies targeting P2X7 receptors could be novel adjunctive treatments for drug-refractory status epilepticus.