Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood.
Shahnaz HaqueRyan M AmesKaren MooreBenjamin P LeeNicola JefferyLorna W HarriesPublished in: BMC medical genomics (2020)
Our data suggest that circRNAs are abundantly expressed in human islets, and that some are differentially regulated in the islets of donors with type 2 diabetes. Some islet circRNAs are also expressed in peripheral blood and the expression of one, circCAMSAP1, correlates with diabetes status. These findings highlight the potential of circRNAs as biomarkers for T2D.