Familial Mediterranean fever: perspective on female fertility and disease course in pregnancy from a multicenter nationwide network.
Fatma Gül YurdakulHatice BodurHasan Fatih CayÜlkü UçarYasar KeskinBetül SarginGülcan GürerOzan Volkan YurdakulMustafa ÇalışHülya DeveciYildiray AydinSami HİzmetlİRemzi CevikAli Yavuz KarahanŞebnem AtamanMehmet Tuncay DuruözHilal KocabaşNesrin ŞenMurat ToprakNesrin ŞenDuygu AltıntaşAhmet Kıvanç CengizGökhan ÇağlayanAli Nail DemirHüseyin KaplanSertaç KetenciMeltem Alkan MelikogluMehmet NayimoğluKemal NasAyşe Banu SarıfakıoğluIlhan SezerPublished in: Rheumatology international (2023)
The aim of this study was to analyze the pregnancy process, especially the Familial Mediterranean fever (FMF) disease course and attack types during pregnancy, and to examine the relationship between disease-related factors and female infertility in FMF patients. The study, which was planned in a multicenter national network, included 643 female patients. 435 female patients who had regular sexual intercourse were questioned in terms of infertility. Pregnancy and delivery history, FMF disease severity and course during pregnancy were evaluated. The relationship between demographic and clinical findings, disease severity, genetic analysis results and infertility was investigated. 401 patients had at least 1 pregnancy and 34 patients were diagnosed with infertility. 154 patients had an attack during pregnancy. 61.6% of them reported that attacks during pregnancy were similar to those when they were not pregnant. The most common attack symptoms were fever, fatigue and abdominal pain-peritonitis (96%, 87%, and 83%, respectively) in the pregnancy period. The disease-onset age, disease activity score, gene mutation analyses, and regular colchicine use (> 90%) were similar between the fertile and infertile groups, while the frequency of previous appendectomy and alcohol consumption rates were higher in individuals with infertility. Our results indicated no significant change in the frequency and severity of attacks during pregnancy. The low rate of infertility (7.8%) in our patients was noted. It has been suggested that the risk of FMF-related infertility may not be as high as thought in patients who are followed up regularly and received colchicine.
Keyphrases
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- peritoneal dialysis
- clinical trial
- pregnant women
- systemic lupus erythematosus
- insulin resistance
- patient reported outcomes
- young adults
- polycystic ovary syndrome
- alcohol consumption
- cross sectional
- early onset
- abdominal pain
- ankylosing spondylitis
- rheumatoid arthritis patients