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Monascus-fermented red mold dioscorea protects mice against alcohol-induced liver injury, whereas its metabolites ankaflavin and monascin regulate ethanol-induced peroxisome proliferator-activated receptor-γ and sterol regulatory element-binding transcription factor-1 expression in HepG2 cells.

Chih-Fu ChengTzu-Ming Pan
Published in: Journal of the science of food and agriculture (2017)
These results indicate the hepatoprotective effect of Monascus-fermented RMD. Moreover, AK and MS were identified as the active constituents of RMD for the first time and were shown to protect against ethanol-induced liver damage. © 2017 Society of Chemical Industry.
Keyphrases
  • transcription factor
  • high glucose
  • diabetic rats
  • ms ms
  • oxidative stress
  • poor prognosis
  • binding protein
  • mass spectrometry
  • drug induced
  • dna binding
  • type diabetes
  • endothelial cells
  • lactic acid
  • high fat diet induced