Epidemiological, clinical and laboratory aspects of human visceral leishmaniasis (HVL) associated with human immunodeficiency virus (HIV) coinfection: a systematic review.
Iolanda Graepp FontouraDavid Soeiro BarbosaAntonio Marcus de Andrade PaesFloriacy Stabnow SantosMarcelino Santos NetoVolmar Morais FontouraJackson Mauricio Lopes CostaAna Lúcia Abreu-SilvaPublished in: Parasitology (2018)
Coinfection with human visceral leishmaniasis (HVL) and human immunodeficiency virus (HIV) has become an emerging public health problem in several parts of the world, with high morbidity and mortality rates. A systematic review was carried out in the literature available in PubMed, Scielo and Lilacs related to HVL associated with HIV coinfection, seeking to analyze epidemiological, clinical and laboratory aspects. Of the 265 articles found, 15 articles were included in the qualitative analysis, which referred to the results of HVL treatment in patients coinfected with HIV. In the published articles between 2007 and 2015, 1171 cases of HVL/HIV coinfection were identified, 86% males, average age 34 years, liposomal amphotericin B was the most commonly used drug, cure rates 68 and 20% relapses and 19% deaths, five different countries, bone marrow was used in 10/15 manuscripts. HVL/HIV coinfection is a major challenge for public health, mainly due to the difficulty in establishing an accurate diagnosis, low response to treatment with high relapse rates and evolution to death. In addition, these two pathogens act concomitantly for the depletion of the immune system, contributing to worsening the clinical picture of these diseases, which requires effective surveillance and epidemiological control measures.
Keyphrases
- human immunodeficiency virus
- antiretroviral therapy
- hiv infected
- hepatitis c virus
- hiv positive
- public health
- hiv aids
- hiv testing
- bone marrow
- men who have sex with men
- endothelial cells
- systematic review
- randomized controlled trial
- south africa
- high resolution
- mental health
- mass spectrometry
- antimicrobial resistance
- combination therapy
- pluripotent stem cells