Gene expression profile following an oral unsaturated fat load in abdominal obese subjects.
A Bárbara Garcia-GarciaSergio Martinez-HervasJ T RealP Marin-GarciaG de MarcoA PriegoJ F Martínez-VallsR CarmenaF J ChavesJ F AscasoPublished in: European journal of nutrition (2018)
Our results suggest that an OFLT rich in unsaturated fatty acids downregulates the expression of FKBP5, coding for the glucocorticoid receptor pathway, and that of DDIT4, involved in the oxidative stress response. These changes could favourably influence the insulin resistance and oxidative stress status in the postprandial state.
Keyphrases
- adipose tissue
- insulin resistance
- fatty acid
- gene expression
- oxidative stress
- metabolic syndrome
- poor prognosis
- high fat diet
- type diabetes
- binding protein
- dna methylation
- weight loss
- polycystic ovary syndrome
- dna damage
- blood glucose
- ischemia reperfusion injury
- high fat diet induced
- induced apoptosis
- skeletal muscle
- obese patients
- long non coding rna
- blood pressure
- bariatric surgery
- heat shock protein