Exosome miR-27a-3p secreted from adipocytes targets ICOS to promote antitumor immunity in lung adenocarcinoma.
Xuehan FanJingya WangTingting QinYujia ZhangWenting LiuKaiting JiangDingzhi HuangPublished in: Thoracic cancer (2020)
Adipocyte-derived exo-miR-27a-3p can inhibit ICOS+ T cell proliferation and IFN-gamma secretion. The upregulation of ICOS+ T cell functions caused by the downregulation of miR-27a-3p in adipose tissue derived exosomes is one of the potential mechanisms for the improved efficacy of immunotherapy in obese LUAD patients.
Keyphrases
- adipose tissue
- cell proliferation
- insulin resistance
- end stage renal disease
- high fat diet
- newly diagnosed
- ejection fraction
- signaling pathway
- chronic kidney disease
- mesenchymal stem cells
- stem cells
- prognostic factors
- type diabetes
- peritoneal dialysis
- poor prognosis
- metabolic syndrome
- fatty acid
- long non coding rna
- skeletal muscle