Anti-acetylated-tau immunotherapy is neuroprotective in tauopathy and brain injury.
Celeste Parra BravoKaren KrukowskiSarah BarkerChao WangYaqiao LiLi FanEdwin Vázquez-RosaMin-Kyoo ShinMan Ying WongLouise D McCulloughRyan S KitagawaH Alex ChoiAngela CacaceSubhash C SinhaAndrew A PieperSusanna RosiXu ChenLi GanPublished in: Molecular neurodegeneration (2024)
The ability of anti-ac-tauK174 treatment to rescue neurobehavioral impairment, reduce tau pathology, and rescue glial responses demonstrates that targeting tau acetylation at K174 is a promising neuroprotective therapeutic approach to human tauopathies resulting from TBI or genetic disease.
Keyphrases
- brain injury
- cerebral ischemia
- subarachnoid hemorrhage
- cerebrospinal fluid
- endothelial cells
- traumatic brain injury
- neuropathic pain
- genome wide
- cancer therapy
- induced pluripotent stem cells
- blood brain barrier
- pluripotent stem cells
- severe traumatic brain injury
- dna methylation
- gene expression
- spinal cord
- mild traumatic brain injury
- spinal cord injury
- drug delivery