Additive effect of erythropoietin use on exercise-induced endothelial activation and hypercoagulability in athletes.
Jules A A C HeubergerJelle J PosthumaDimitrios ZiagkosJoris I RotmansJohannes M A DanielsPim GalFrederik E StuurmanHenri M H SpronkHugo Ten CateJacobus BurggraafMatthijs MoerlandAdam F CohenPublished in: European journal of applied physiology (2020)
In conclusion, rHuEPO treatment resulted in elevated E- and P-selectin levels in trained cyclists, indicating enhanced endothelial activation and/or platelet reactivity. Exercise itself induces hypercoagulability, and the combination of rHuEPO and exercise increased E-selectin and PF4 levels more than either intervention alone. Based on this, exercise potentially increases thrombotic risk, a risk that might be enhanced in combination with rHuEPO use.