Shining a FLASHlight on Ultrahigh Dose-Rate Radiation and Possible Late Toxicity.

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

A recent study reported results from a clinical trial in cats and from experiments in mini-pigs in which a single dose of radiotherapy was delivered at ultrahigh dose rates (FLASH). There was acceptable acute toxicity; however, some animals suffered severe late toxicity, raising caution in the design of future trials. See related article by Rohrer Bley et al., p. 3814.

Keyphrases

clinical trial
oxidative stress
liver failure
drug induced
early stage
radiation induced
radiation therapy
early onset
respiratory failure
locally advanced
randomized controlled trial
intensive care unit
open label
extracorporeal membrane oxygenation
mechanical ventilation