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Gastric Plication Improves Glycemia Partly by Restoring the Altered Expression of Aquaglyceroporins in Adipose Tissue and the Liver in Obese Rats.

Leire Méndez-GiménezSara BecerrilRafael MoncadaVíctor ValentíSecundino FernándezBeatriz RamírezVictoria CatalánJavier Gómez-AmbrosiGraça SoveralMaría M MalagónCarlos DiéguezAmaia RodríguezGema Frühbeck
Published in: Obesity surgery (2018)
Gastric plication results in a modest reduction in adiposity and hepatosteatosis but restores glycemia by downregulating AQP3, which entails lower efflux of glycerol from fat, lower plasma glycerol availability, and a reduced use of glycerol as a substrate for hepatic gluconeogenesis.
Keyphrases
  • adipose tissue
  • insulin resistance
  • high fat diet
  • poor prognosis
  • metabolic syndrome
  • type diabetes
  • weight loss
  • physical activity
  • fatty acid
  • weight gain