MC1568 improves insulin secretion in islets from type 2 diabetes patients and rescues β-cell dysfunction caused by Hdac7 upregulation.
Mahboubeh DaneshpajoohLena EliassonKarl BacosCharlotte LingPublished in: Acta diabetologica (2018)
HDAC7 inhibition protects β-cells from mitochondrial dysfunction and apoptosis, and increases glucose-stimulated insulin secretion in islets from human T2D donors. Our study supports specific HDAC7 inhibitors as novel options in the treatment of T2D.
Keyphrases
- type diabetes
- histone deacetylase
- end stage renal disease
- oxidative stress
- ejection fraction
- endothelial cells
- chronic kidney disease
- newly diagnosed
- single cell
- cardiovascular disease
- prognostic factors
- endoplasmic reticulum stress
- poor prognosis
- cell death
- mouse model
- patient reported outcomes
- insulin resistance
- combination therapy
- induced pluripotent stem cells
- pluripotent stem cells
- replacement therapy