Paediatric morphoea: a holistic review. Part 2: diagnosis, measures of disease activity, management and natural history.
Akanksha KaushikRahul MahajanDipankar DeSanjeev HandaPublished in: Clinical and experimental dermatology (2020)
Paediatric morphoea is a debilitating fibrosing disorder of uncertain aetiology, affecting the skin and subcutaneous tissues. Defining optimum management strategies in paediatric morphoea remains an ongoing challenge, owing to the varied presentations and a relative paucity of paediatric-specific studies. We performed a literature search on PubMed, MEDLINE and Google Scholar, using keywords such as 'pediatric morphea', 'juvenile localised scleroderma' and 'juvenile systemic sclerosis'. Relevant studies, including randomized trials, reviews of standard current guidelines and original research articles, were selected and results analysed before summarizing them. In Part 1 of this review, we described the epidemiology, aetiopathogenesis and clinical classification; in this part, we discuss the diagnosis, markers of disease activity, management and natural history in paediatric morphoea.
Keyphrases
- disease activity
- systemic sclerosis
- rheumatoid arthritis
- interstitial lung disease
- systemic lupus erythematosus
- intensive care unit
- rheumatoid arthritis patients
- emergency department
- ankylosing spondylitis
- juvenile idiopathic arthritis
- systematic review
- machine learning
- gene expression
- deep learning
- randomized controlled trial
- risk factors
- case control
- meta analyses