The role of human CD46 in early xenoislet engraftment in a dual transplant model.
Kannan P SamyQimeng GaoRobert Patrick DavisMingqing SongZachary W FitchMichael S MulvihillAndrea L MacDonaldFrank V LeopardiTam HowKyha D WilliamsGayathri R DeviBradley H CollinsXunrong LuoAllan D KirkPublished in: Xenotransplantation (2019)
Our findings suggest that expression of hCD46 on NPIs potentially provides a measurable incremental survival advantage in vivo by reducing early thrombo-inflammatory events associated with instant blood-mediated inflammatory reaction (IBMIR) following intraportal islet infusion.