The peripheral blood transcriptome in septic cardiomyopathy: an observational, pilot study.
Meghan M CirulisSarah J BeesleyEmily L WilsonChris StubbenTroy D OlsenEliotte L HirshbergLane M SmithMichael J LanspaTheodore P AbrahamColin K GrissomMatthew T RondinaSamuel M BrownPublished in: Intensive care medicine experimental (2019)
In this hypothesis-generating study, SCM was associated with upregulation of genes in the type 1 interferon signaling pathway. Interferons are cytokines that stimulate the innate and adaptive immune response and are implicated in the early proinflammatory and delayed immunosuppression phases of sepsis. While type 1 interferons have not been implicated previously in SCM, interferon therapy (for viral hepatitis and Kaposi sarcoma) has been associated with reversible cardiomyopathy, perhaps suggesting a role for interferon signaling in SCM.
Keyphrases
- immune response
- dendritic cells
- signaling pathway
- peripheral blood
- acute kidney injury
- heart failure
- genome wide
- intensive care unit
- sars cov
- cell proliferation
- gene expression
- pi k akt
- rna seq
- poor prognosis
- epithelial mesenchymal transition
- single cell
- cross sectional
- septic shock
- atrial fibrillation
- induced apoptosis
- transcription factor
- endoplasmic reticulum stress
- inflammatory response
- bioinformatics analysis