Psychological Distress in Young Adults with Acute Myeloid Leukemia Undergoing Induction Chemotherapy.
Bethany J LockwoodAreej El-JawahriAlison R WalkerSarah EhrmanDeborah RussellSachin S KaleJillian GustinSeuli Bose-BrillThomas W LeBlancSelina M LugerMaryam LustbergBhavana BhatnagarPublished in: Journal of adolescent and young adult oncology (2022)
Young adults (YAs), aged 18-39 years, with acute myeloid leukemia (AML) navigate life disruptions amid an unpredictable illness trajectory. We conducted a secondary analysis of patient-reported outcomes for hospitalized YAs with high-risk AML receiving intensive chemotherapy, collected during a multisite randomized clinical trial. Of the 160 patients, 14 (8.8%) were YAs. At week 2 of hospitalization, YAs demonstrated significant worse quality of life (β = -18.27; p = 0.036), higher anxiety (β = 2.72; p = 0.048), and higher post-traumatic stress disorder (PTSD; β = 10.34; p = 0.007) compared with older adults. Our analysis demonstrated a longitudinal presence of anxiety and PTSD, suggesting persistent unmet psychological needs for YAs with AML.
Keyphrases
- acute myeloid leukemia
- patient reported outcomes
- young adults
- allogeneic hematopoietic stem cell transplantation
- sleep quality
- end stage renal disease
- social support
- ejection fraction
- newly diagnosed
- locally advanced
- physical activity
- chronic kidney disease
- peritoneal dialysis
- posttraumatic stress disorder
- depressive symptoms
- radiation therapy
- randomized controlled trial
- clinical trial
- stress induced
- acute lymphoblastic leukemia
- chemotherapy induced
- data analysis