Real-life multidisciplinary treatment for unresectable colorectal cancer liver metastases including hepatic artery infusion with chemo-filtration and liquid biopsy precision oncotherapy: observational cohort study.
Stefano GuadagniMarco ClementiAndrew R MackayEnrico RicevutoGiammaria FiorentiniDonatella SartiPaola PalumboPanagiotis ApostolouIoannis PapasotiriouFrancesco MaseduMarco ValentiAldo Victor GiordanoGemma BrueraPublished in: Journal of cancer research and clinical oncology (2020)
HAI plus chemo-filtration followed by target therapy, with drug regimens selected by liquid biopsy precision oncotherapy, is a safe and efficacious alternative therapeutic strategy for unresectable CRCLM in progression after two lines of systemic therapy and should be considered for a multicentre prospective phase III study, to fully confirm this potential.
Keyphrases
- liver metastases
- phase iii
- locally advanced
- clinical trial
- photodynamic therapy
- combination therapy
- open label
- double blind
- ultrasound guided
- ionic liquid
- fine needle aspiration
- cancer therapy
- squamous cell carcinoma
- low dose
- study protocol
- rectal cancer
- randomized controlled trial
- stem cells
- placebo controlled
- cross sectional
- climate change
- replacement therapy
- human health
- quality improvement
- smoking cessation