Clinical outcome of ulcerative colitis with severe onset in children: a multicenter prospective cohort study.
Ryusuke NambuKatsuhiro AraiTakahiro KudoTakatsugu MurakoshiReiko KunisakiTatsuki MizuochiSawako KatoHideki KumagaiMikihiro InoueTakashi IshigeTakeshi SaitoAtsuko NoguchiToshifumi YodoshiShin-Ichiro HagiwaraNaomi IwataShigeo NishimataFumihiko KakutaHitoshi TajiriEitaro HiejimaNariaki ToitaTakahiro MochizukiHirotaka ShimizuItaru IwamaYuri HiranoToshiaki Shimizunull nullPublished in: Journal of gastroenterology (2023)
Children with severe ulcerative colitis are likely to require powerful agents such as calcineurin inhibitors and biologic agents; sometimes colectomy ultimately proves necessary. Need for biologic agents in steroid-resistant patients might be reduced to an extent by interposing a therapeutic trial of CI rather than turning to biologic agents or colectomy immediately.