Novel strategies for the treatment of acetaminophen hepatotoxicity.
Jephte Yao AkakpoAnup RamachandranHartmut JaeschkePublished in: Expert opinion on drug metabolism & toxicology (2020)
Fomepizole (4-methylpyrazole) is safe and has shown efficacy in preclinical models, human hepatocytes and in volunteers against APAP overdose. The safety of calmangafodipir in APAP overdose patients was shown but it lacks solid preclinical efficacy studies. Both drugs require a controlled phase III trial to achieve regulatory approval. All studies of herbal medicine extracts and components suffer from poor experimental design, which questions their clinical utility at this point.
Keyphrases
- phase iii
- open label
- clinical trial
- end stage renal disease
- phase ii
- newly diagnosed
- liver injury
- endothelial cells
- drug induced
- chronic kidney disease
- ejection fraction
- case control
- prognostic factors
- study protocol
- transcription factor
- randomized controlled trial
- double blind
- peritoneal dialysis
- combination therapy
- patient reported