Hartmut Jaeschke (H Jaeschke)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 71

Top Venues

Archives of toxicology

Livers

Toxicological sciences : an official journal of the Society of Toxicology

Expert review of clinical pharmacology

University of Kansas Medical Center

University of Tuebingen (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Kansas Medical Center Jan 10 2012

United States

Chairman :: Pharmacology, Toxicology & Therapeutics

University of Kansas Medical Center Sep 01 2006 - Jun 30 2019

United States

Professor :: Pharmacology, Toxicology & Therapeutics

University of Arizona Oct 16 2002 - Aug 31 2006

United States

Professor and Assoc. Director Liver Research Institute :: Pharmacology

University of Arkansas for Medical Sciences Jan 01 1999 - Oct 15 2002

United States

Professor :: Pharmacology & Toxicology

The Upjohn Company/Pharmacia & Upjohn, Inc Oct 16 1992 - Dec 31 1998

United States

Senior Scientist IV :: Drug Metabolism Research / Pharmacology

Baylor College of Medicine Jul 01 1987 - Oct 15 1992

United States

Asst/Assoc Professor :: Medicine

Education History

University of Tuebingen Jul 01 1981 - Jul 01 1983

Germany

PHD :: Toxicology

University of Tuebingen Oct 01 1975 - Jul 01 1981

Germany

MSC :: Biochemistry

Publications

David S Umbaugh, Hartmut Jaeschke
Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight. Expert review of clinical pharmacology 17 (2) (2024)
Hartmut Jaeschke, Anup Ramachandran
Comments on: Unveiling the therapeutic promise of natural products in alleviating drug-induced liver injury: Present advancements and future prospects. Phytotherapy research : PTR 38 (4) (2024)
Olamide B Adelusi, Jephte Y Akakpo, Gary Eichenbaum, Ejaz Sadaff, Anup Ramachandran, Hartmut Jaeschke
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice. Archives of toxicology 98 (6) (2024)
Olamide B Adelusi, Jephte Y Akakpo, Gary Eichenbaum, Ejaz Sadaff, Anup Ramachandran, Hartmut Jaeschke
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice. Archives of toxicology 98 (6) (2024)
Hartmut Jaeschke, Anup Ramachandran
Comments on: Unveiling the therapeutic promise of natural products in alleviating drug-induced liver injury: Present advancements and future prospects. Phytotherapy research : PTR 38 (4) (2024)
Jephte Yao Akakpo, Hernando Olivos, Bindesh Shrestha, Anthony Midey, Hartmut Jaeschke, Anup Ramachandran
Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging. Toxicological sciences : an official journal of the Society of Toxicology 198 (2) (2024)
Jephte Yao Akakpo, Hernando Olivos, Bindesh Shrestha, Anthony Midey, Hartmut Jaeschke, Anup Ramachandran
Spatial analysis of renal acetaminophen metabolism and its modulation by 4-methylpyrazole with DESI mass spectrometry imaging. Toxicological sciences : an official journal of the Society of Toxicology 198 (2) (2024)
Hartmut Jaeschke, Anup Ramachandran
Comments on: Unveiling the therapeutic promise of natural products in alleviating drug-induced liver injury: Present advancements and future prospects. Phytotherapy research : PTR 38 (4) (2024)
Hartmut Jaeschke, Anup Ramachandran
Comments on: Unveiling the therapeutic promise of natural products in alleviating drug-induced liver injury: Present advancements and future prospects. Phytotherapy research : PTR 38 (4) (2024)
David S Umbaugh, Hartmut Jaeschke
Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight. Expert review of clinical pharmacology 17 (2) (2024)
Olamide B Adelusi, Jephte Y Akakpo, Gary Eichenbaum, Ejaz Sadaff, Anup Ramachandran, Hartmut Jaeschke
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice. Archives of toxicology 98 (6) (2024)
Hartmut Jaeschke, Anup Ramachandran
Comments on: Unveiling the therapeutic promise of natural products in alleviating drug-induced liver injury: Present advancements and future prospects. Phytotherapy research : PTR (2024)
David S Umbaugh, Hartmut Jaeschke
Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight. Expert review of clinical pharmacology 17 (2) (2024)
Olamide B Adelusi, Yasaman Etemadi, Jephte Yao Akakpo, Anup Ramachandran, Hartmut Jaeschke
Effect of ferroptosis inhibitors in a murine model of acetaminophen-induced liver injury. Journal of biochemical and molecular toxicology 38 (8) (2024)
David S Umbaugh, Hartmut Jaeschke
Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight. Expert review of clinical pharmacology 17 (2) (2024)
Olamide B Adelusi, Jephte Y Akakpo, Gary Eichenbaum, Ejaz Sadaff, Anup Ramachandran, Hartmut Jaeschke
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice. Archives of toxicology 98 (6) (2024)
Chao Xu, Fang Yan, Yulan Zhao, Hartmut Jaeschke, Jianguo Wu, Li Fang, Lifang Zhao, Yuanfei Zhao, Li Wang
Hepatocyte miR-21-5p-deficiency alleviates APAP-induced liver injury by inducing PPARγ and autophagy. Toxicological sciences : an official journal of the Society of Toxicology 198 (1) (2024)
David S Umbaugh, Hartmut Jaeschke
Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight. Expert review of clinical pharmacology (2024)
Hartmut Jaeschke, Anup Ramachandran
Comments on: Unveiling the therapeutic promise of natural products in alleviating drug-induced liver injury: Present advancements and future prospects. Phytotherapy research : PTR (2024)
Olamide B Adelusi, Jephte Y Akakpo, Gary Eichenbaum, Ejaz Sadaff, Anup Ramachandran, Hartmut Jaeschke
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice. Archives of toxicology 98 (6) (2024)
Chao Xu, Fang Yan, Yulan Zhao, Hartmut Jaeschke, Jianguo Wu, Li Fang, Lifang Zhao, Yuanfei Zhao, Li Wang
Hepatocyte miR-21-5p-deficiency alleviates APAP-induced liver injury by inducing PPARγ and autophagy. Toxicological sciences : an official journal of the Society of Toxicology 198 (1) (2024)
Olamide B Adelusi, Yasaman Etemadi, Jephte Yao Akakpo, Anup Ramachandran, Hartmut Jaeschke
Effect of ferroptosis inhibitors in a murine model of acetaminophen-induced liver injury. Journal of biochemical and molecular toxicology 38 (8) (2024)
David S Umbaugh, Hartmut Jaeschke
Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight. Expert review of clinical pharmacology (2024)
David S Umbaugh, Hartmut Jaeschke
Biomarker discovery in acetaminophen hepatotoxicity: leveraging single-cell transcriptomics and mechanistic insight. Expert review of clinical pharmacology 17 (2) (2024)
Olamide B Adelusi, Jephte Y Akakpo, Gary Eichenbaum, Ejaz Sadaff, Anup Ramachandran, Hartmut Jaeschke
The thrombopoietin mimetic JNJ-26366821 reduces the late injury and accelerates the onset of liver recovery after acetaminophen-induced liver injury in mice. Archives of toxicology (2024)
Giselle Sanchez-Guerrero, David S Umbaugh, Abhay A Ramachandran, Antonio Artigues, Hartmut Jaeschke, Anup Ramachandran
Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose. Livers 4 (1) (2023)
Allyn Bryan, Pavani Pingali, Anthony Faber, Joseph Landry, Jephte Akakpo, Hartmut Jaeschke, Howard Li, Won Lee, Lauren May, Bhaumik Patel, Alexander Neuwelt
High dose acetaminophen with concurrent CYP2E1 inhibition has profound anti-cancer activity without liver toxicity . The Journal of pharmacology and experimental therapeutics (2023)
Giselle Sanchez-Guerrero, David S Umbaugh, Abhay A Ramachandran, Antonio Artigues, Hartmut Jaeschke, Anup Ramachandran
Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose. Livers 4 (1) (2023)
Anup Ramachandran, Hartmut Jaeschke
Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review. Livers 3 (2) (2023)
Anup Ramachandran, Hartmut Jaeschke
Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review. Livers 3 (2) (2023)
Yasaman Etemadi, Jephte Y Akakpo, Anup Ramachandran, Hartmut Jaeschke
Nrf2 as a therapeutic target in acetaminophen hepatotoxicity: A case study with sulforaphane. Journal of biochemical and molecular toxicology (2023)
Nga T Nguyen, David S Umbaugh, Sawyer Smith, Olamide B Adelusi, Giselle Sanchez-Guerrero, Anup Ramachandran, Hartmut Jaeschke
Dose-dependent pleiotropic role of neutrophils during acetaminophen-induced liver injury in male and female mice. Archives of toxicology (2023)
Giselle Sanchez-Guerrero, David S Umbaugh, Abhay A Ramachandran, Antonio Artigues, Hartmut Jaeschke, Anup Ramachandran
Translocation of Adenosine A2B Receptor to Mitochondria Influences Cytochrome P450 2E1 Activity after Acetaminophen Overdose. Livers 4 (1) (2023)
Hartmut Jaeschke, Anup Ramachandran
Central mechanisms of acetaminophen hepatotoxicity: mitochondrial dysfunction by protein adducts and oxidant stress. Drug metabolism and disposition: the biological fate of chemicals (2023)
Anup Ramachandran, Hartmut Jaeschke
Mitochondria in Acetaminophen-Induced Liver Injury and Recovery: A Concise Review. Livers 3 (2) (2023)
Hartmut Jaeschke, David S Umbaugh, Anup Ramachandran
Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity. Livers 2 (4) (2022)
Nga T Nguyen, David S Umbaugh, Eileen L Huang, Olamide B Adelusi, Giselle Sanchez Guerrero, Anup Ramachandran, Hartmut Jaeschke
Recovered Hepatocytes Promote Macrophage Apoptosis Through CXCR4 After Acetaminophen-Induced Liver Injury in Mice. Toxicological sciences : an official journal of the Society of Toxicology 188 (2) (2022)
Jephte Yao Akakpo, Matthew Wolfgang Jaeschke, Yasaman Etemadi, Antonio Artigues, Scott Toerber, Hernando Olivos, Bindesh Shrestha, Anthony Midey, Hartmut Jaeschke, Anup Ramachandran
Desorption Electrospray Ionization Mass Spectrometry Imaging Allows Spatial Localization of Changes in Acetaminophen Metabolism in the Liver after Intervention with 4-Methylpyrazole. Journal of the American Society for Mass Spectrometry 33 (11) (2022)
Hartmut Jaeschke, Anup Ramachandran
Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice. Microbiology spectrum 11 (1) (2022)
Hartmut Jaeschke
Acetaminophen Hepatotoxicity: Not as Simple as One Might Think! Introductory Comments on the Special Issue- Recent Advances in Acetaminophen Hepatotoxicity . Livers 2 (3) (2022)
Joel H Vazquez, Stefanie Kennon-McGill, Stephanie D Byrum, Samuel G Mackintosh, Hartmut Jaeschke, D Keith Williams, William M Lee, Jonathan A Dranoff, Mitchell R McGill, null null
Proteomics Indicates Lactate Dehydrogenase Is Prognostic in Acetaminophen-Induced Acute Liver Failure Patients and Reveals Altered Signaling Pathways. Toxicological sciences : an official journal of the Society of Toxicology 187 (1) (2022)
Hartmut Jaeschke, Anup Ramachandran
Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice. Microbiology spectrum 11 (1) (2022)
Hartmut Jaeschke, Anup Ramachandran
Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice. Microbiology spectrum 11 (1) (2022)
Hartmut Jaeschke, Anup Ramachandran
Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice. Microbiology spectrum 11 (1) (2022)
Hartmut Jaeschke, David S Umbaugh, Anup Ramachandran
Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity. Livers 2 (4) (2022)
Jephte Y Akakpo, Anup Ramachandran, Steven C Curry, Barry H Rumack, Hartmut Jaeschke
Comparing N-acetylcysteine and 4-methylpyrazole as antidotes for acetaminophen overdose. Archives of toxicology 96 (2) (2022)
Hartmut Jaeschke, Anup Ramachandran
Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice. Microbiology spectrum (2022)
Samikshya Poudel, Diego Paine Cabrera, Bharat Bhushan, Michael W Manley, Sumedha Gunewardena, Hartmut Jaeschke, Udayan Apte
Hepatocyte-Specific Deletion of Yes-Associated Protein Improves Recovery From Acetaminophen-Induced Acute Liver Injury. Toxicological sciences : an official journal of the Society of Toxicology 184 (2) (2022)
Hartmut Jaeschke, David S Umbaugh, Anup Ramachandran
Role of Pyroptosis in Acetaminophen-Induced Hepatotoxicity. Livers 2 (4) (2022)
Devadoss J Samuvel, Nga T Nguyen, Hartmut Jaeschke, John J Lemasters, Xiaojuan Wang, Yeun-Mun Choo, Mark T Hamann, Zhi Zhong
Platanosides, a Potential Botanical Drug Combination, Decrease Liver Injury Caused by Acetaminophen Overdose in Mice. Journal of natural products 85 (7) (2022)
David S Umbaugh, Rupal P Soder, Nga T Nguyen, Olamide Adelusi, Dakota R Robarts, Ben Woolbright, Luqi Duan, Sunil Abhyankar, Buddhadeb Dawn, Udayan Apte, Hartmut Jaeschke, Anup Ramachandran
Human Wharton's Jelly-derived mesenchymal stem cells prevent acetaminophen-induced liver injury in a mouse model unlike human dermal fibroblasts. Archives of toxicology 96 (12) (2022)
Hartmut Jaeschke, Anup Ramachandran
Putative Effects of an Orally Administered Anti-TLR4 Antibody on Gut Microbiota and Acetaminophen Hepatotoxicity in Mice. Microbiology spectrum 11 (1) (2022)
Nga T Nguyen, Jephte Y Akakpo, James L Weemhoff, Anup Ramachandran, Wen-Xing Ding, Hartmut Jaeschke
Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice. Archives of toxicology 95 (4) (2021)
Deqiang Zhang, Sujuan Wang, Erin Ospina, Omar Shabandri, Daniel Lank, Jephte Y Akakpo, Zifeng Zhao, Meichan Yang, Jun Wu, Hartmut Jaeschke, Pradip Saha, Xin Tong, Lei Yin
Fructose Protects Against Acetaminophen-Induced Hepatotoxicity Mainly by Activating the Carbohydrate-Response Element-Binding Protein α-Fibroblast Growth Factor 21 Axis in Mice. Hepatology communications 5 (6) (2021)
David S Umbaugh, Anup Ramachandran, Hartmut Jaeschke
Spatial Reconstruction of the Early Hepatic Transcriptomic Landscape After an Acetaminophen Overdose Using Single-Cell RNA-Sequencing. Toxicological sciences : an official journal of the Society of Toxicology 182 (2) (2021)
Anup Ramachandran, David S Umbaugh, Hartmut Jaeschke
Mitochondrial Dynamics in Drug-Induced Liver Injury. Livers 1 (3) (2021)
Anup Ramachandran, Hartmut Jaeschke
Oxidant Stress and Acetaminophen Hepatotoxicity: Mechanism-Based Drug Development. Antioxidants & redox signaling 35 (9) (2021)
Hartmut Jaeschke, Anup Ramachandran
Does acetaminophen hepatotoxicity involve apoptosis, inflammatory liver injury, and lipid peroxidation? Journal of biochemical and molecular toxicology 35 (2) (2021)
Jephte Y Akakpo, Matthew W Jaeschke, Anup Ramachandran, Steven C Curry, Barry H Rumack, Hartmut Jaeschke
Delayed administration of N-acetylcysteine blunts recovery after an acetaminophen overdose unlike 4-methylpyrazole. Archives of toxicology 95 (10) (2021)
Nga T Nguyen, David S Umbaugh, Giselle Sanchez-Guerrero, Anup Ramachandran, Hartmut Jaeschke
Kupffer cells regulate liver recovery through induction of chemokine receptor CXCR2 on hepatocytes after acetaminophen overdose in mice. Archives of toxicology (2021)
Hartmut Jaeschke, Anup Ramachandran
Letter to the Editor: Does c-Jun N-Terminal Kinase Regulate Acetaminophen Hepatotoxicity by Modulating Nuclear Factor Erythroid 2-Related Factor 2-Dependent Genes or Mitochondrial Oxidant Stress? Hepatology (Baltimore, Md.) 73 (1) (2020)
David S Umbaugh, Hartmut Jaeschke
Biomarkers of drug-induced liver injury: a mechanistic perspective through acetaminophen hepatotoxicity. Expert review of gastroenterology & hepatology 15 (4) (2020)
Hartmut Jaeschke, Anup Ramachandran
Letter to the Editor Regarding the Article "Chrysin Effect in Prevention of Acetaminophen-Induced Hepatotoxicity in Rat" by Mohammadi and Co-Workers (2019). Chemical research in toxicology 33 (3) (2020)
Jephte Yao Akakpo, Anup Ramachandran, Hartmut Jaeschke
Novel strategies for the treatment of acetaminophen hepatotoxicity. Expert opinion on drug metabolism & toxicology 16 (11) (2020)
Hartmut Jaeschke, Anup Ramachandran
Pleiotropic Roles of Platelets and Neutrophils in Cell Death and Recovery During Acetaminophen Hepatotoxicity. Hepatology (Baltimore, Md.) 72 (5) (2020)
Hartmut Jaeschke, Anup Ramachandran, Xiaojuan Chao, Wen-Xing Ding
Emerging and established modes of cell death during acetaminophen-induced liver injury. Archives of toxicology 93 (12) (2019)
J Y Akakpo, A Ramachandran, S E Kandel, H M Ni, S C Kumer, B H Rumack, Hartmut Jaeschke
4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes. Human & experimental toxicology 37 (12) (2018)
Xiaojuan Chao, Hua Wang, Hartmut Jaeschke, Wen-Xing Ding
Role and mechanisms of autophagy in acetaminophen-induced liver injury. Liver international : official journal of the International Association for the Study of the Liver 38 (8) (2018)
Hartmut Jaeschke
Comments on Caspase-Mediated Anti-Apoptotic Effect of Ginsenoside Rg5, a Main Rare Ginsenoside, on Acetaminophen-Induced Hepatotoxicity in Mice. Journal of agricultural and food chemistry 66 (7) (2018)
Kuo Du, Anup Ramachandran, James L Weemhoff, Benjamin L Woolbright, Andrew H Jaeschke, Xiaojuan Chao, Wen-Xing Ding, Hartmut Jaeschke
Mito-tempo protects against acute liver injury but induces limited secondary apoptosis during the late phase of acetaminophen hepatotoxicity. Archives of toxicology 93 (1) (2018)
Kuo Du, Anwar Farhood, Hartmut Jaeschke
Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity. Archives of toxicology 91 (2) (2016)

Hartmut Jaeschke.css-eqlu8i{font-size:small;padding-left:4px;} (H Jaeschke)

Publication Activity (10 Years)

Top Topics

Top Venues

Hartmut Jaeschke (H Jaeschke)