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Amphiphilic Biaryl Monophosphine Ligands by Regioselective Sulfonation.

Jacob RodriguezHeemal H DhanjeeStephen L Buchwald
Published in: Organic letters (2021)
Amphiphilic ligands are valued for their ability to facilitate organometallic reactions in the presence of water. The regioselective sulfonation of a series of commercially available biaryl monophosphines to generate amphiphilic ligands is presented. In this one-step protocol, the temperature and addition of fuming sulfuric acid were carefully controlled to arrive at sulfonated biaryl monophosphine ligands in high yields with >95% regioselectivity without the need for chromatographic purification.
Keyphrases
  • randomized controlled trial
  • simultaneous determination
  • high resolution