Additives Imparting Antimicrobial Properties to Acrylic Bone Cements.
Alina RobuAurora AntoniacElena GrosuEugeniu VasileAnca Daniela RaiciuFlorin IordacheIulian-Vasile AntoniacJulietta V RauViktoriya G YankovaLia Mara DițuMircea Vicentiu SaceleanuPublished in: Materials (Basel, Switzerland) (2021)
PMMA bone cements are mainly used to fix implanted prostheses and are introduced as a fluid mixture, which hardens over time. The problem of infected prosthesis could be solved due to the development of some new antibacterial bone cements. In this paper, we show the results obtained to develop four different modified PMMA bone cements by using antimicrobial additives, such as gentamicin, peppermint oil incorporated in hydroxyapatite, and silver nanoparticles incorporated in a ceramic glass matrix (2 and 4%). The structure and morphology of the modified bone cements were investigated by SEM and EDS. We perform experimental measurements on wettability, hydration degree, and degradation degree after immersion in simulated body fluid. The cytotoxicity was evaluated by MTT assay using the human MG-63 cell line. Antimicrobial properties were checked against standard strains Staphylococcus aureus, Pseudomonas aeruginosa, and Candida albicans. The addition of antimicrobial agents did not significantly affect the hydration and degradation degree. In terms of biocompatibility assessed by the MTT test, all experimental PMMA bone cements are biocompatible. The performance of bone cements with peppermint essential oil and silver nanoparticles against these two pathogens suggests that these antibacterial additives look promising to be used in clinical practice against bacterial infection.
Keyphrases
- silver nanoparticles
- staphylococcus aureus
- bone mineral density
- soft tissue
- bone regeneration
- candida albicans
- pseudomonas aeruginosa
- bone loss
- biofilm formation
- clinical practice
- essential oil
- postmenopausal women
- ionic liquid
- cystic fibrosis
- body composition
- mass spectrometry
- anti inflammatory
- fatty acid
- high resolution
- single molecule
- lactic acid
- multidrug resistant
- atomic force microscopy
- acinetobacter baumannii