Dysregulation of sphingolipid metabolic enzymes leads to high levels of sphingosine-1-phosphate and ceramide in human hepatocellular carcinoma.
Kohei MiuraMasayuki NagahashiPankaj PrasoonYuki HiroseTakashi KobayashiJun SakataManabu AbeKenji SakimuraYasunobu MatsudaAli L ButashEriko KatsutaKazuaki TakabeToshifumi WakaiPublished in: Hepatology research : the official journal of the Japan Society of Hepatology (2021)
Sphingolipid levels, including S1P and ceramide, were elevated in HCC compared with surrounding normal liver tissue. Our findings suggest S1P plays an important role in HCC tumor progression, and further examination is warranted.