High-intensity interval training reduces neutrophil-to-lymphocyte ratio in persons with multiple sclerosis during inpatient rehabilitation.
Niklas JoistenSebastian ProschingerAnnette RademacherAlexander SchenkWilhelm BlochClemens WarnkeRoman GonzenbachJan KoolJens BansiPhilipp ZimmerPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2020)
In persons with multiple sclerosis (PwMS), the neutrophil-to-lymphocyte ratio (NLR) is associated with disability status, symptomatology and disease activity. High-intensity interval training (HIIT) improves many symptoms in PwMS and may positively influence disease progression. Here, we present results from a randomized controlled trial during inpatient rehabilitation on immediate (single bout) and training (3-week intervention) effects of HIIT versus moderate continuous training on NLR and related cellular inflammation markers. Only HIIT reduced the NLR over the 3-week intervention period. These training effects might be due to repetitive inflammatory states with compensatory anti-inflammatory counterbalancing after each HIIT session.
Keyphrases
- multiple sclerosis
- high intensity
- disease activity
- virtual reality
- randomized controlled trial
- rheumatoid arthritis
- systemic lupus erythematosus
- oxidative stress
- anti inflammatory
- palliative care
- high frequency
- rheumatoid arthritis patients
- white matter
- juvenile idiopathic arthritis
- working memory
- study protocol
- depressive symptoms
- double blind