Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial-Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma.
Samantha GuinnBenedict Kinny-KösterJoseph A TandurellaJacob T MitchellDimitrios N SidiropoulosMelanie LothMelissa R LymanAlexandra B PucsekDaniel J ZabranskyJae W LeeEmma KartaliaMili RamaniToni T SeppäläChristopher M CherryReecha SuriHaley ZlomkeJignasha PatelJin HeChristopher L WolfgangXin YuLei ZhengDavid P RyanDavid Tsai TingAlec C KimmelmanAnuj GuptaLudmila V DanilovaJennifer H ElisseeffLaura D WoodGenevieve L Stein-O'BrienLuciane Tsukamoto KagoharaElizabeth D ThompsonRichard Andrew BurkhartElana J FertigJacquelyn W ZimmermanPublished in: Cancer research (2024)
Adaptation of transfer learning to relate human single-cell RNA sequencing data to organoid-CAF cocultures facilitates discovery of human pancreatic cancer intercellular interactions and uncovers cross-talk between CAFs and tumor cells through VEGFA and ITGB1.