Detection of SARS-CoV-2 RNA and Antibodies in Diverse Samples: Protocol to Validate the Sufficiency of Provider-Observed, Home-Collected Blood, Saliva, and Oropharyngeal Samples.
Patrick Sean SullivanCharles SaileyJodie Lynn GuestJeannette GuarnerColleen F KelleyAaron Julius SieglerMariah Valentine GravesLaura GravensCarlos Del RioTravis Howard SanchezPublished in: JMIR public health and surveillance (2020)
Defining a conceptual framework for assessing the sufficiency of patient-collected samples for the detection of SARS-CoV-2 RNA and serologic responses to infection is critical for facilitating public health responses and providing PPE-sparing options to increase testing. Validation of alternative methods of specimen collection should include objective measures of the sufficiency of specimens for testing. A strong evidence base for diversifying testing modalities will improve tools to guide public health responses to the COVID-19 pandemic.