Expression of clock gene Dbp in omental and mesenteric adipose tissue in patients with type 2 diabetes.

Kentaro UshijimaChisato SuzukiHiroko KitamuraKen ShimadaHirotoshi KawataAkira TanakaHisanaga HorieYoshinori HosoyaYasushi ImaiChikamasa YamashitaAkio Fujimura

Published in: BMJ open diabetes research & care (2021)

The changes in DBP-PPAR-γ axis observed in mice with diabetes were also detected in patients with DM2. Because adiponectin secretion is reported to be enhanced through the PPAR-γ-related mechanism, this study supports the hypothesis that omental adipose tissue is involved in the mechanism of DM2.

Keyphrases

adipose tissue
insulin resistance
glycemic control
high fat diet induced
high fat diet
type diabetes
poor prognosis
metabolic syndrome
cardiovascular disease
skeletal muscle
genome wide
copy number
fatty acid
long non coding rna
dna methylation
weight loss