Mesenchymal stem cell transplantation in polytrauma: Evaluation of bone and liver healing response in an experimental rat model.
Ayça Koca TanrıverdiOnur PolatAyşe Eser ElçinOzan AhlatGünhan GürmanMüge GünalpAhmet Burak OğuzSinan GençYaşar Murat ElçinPublished in: European journal of trauma and emergency surgery : official publication of the European Trauma Society (2019)
Herewith we have shown that MSC infusion in posttraumatic rats leads to less aggressive and more effective consequences on liver and bone tissue healing. Human MSC treatment for trauma is still in early stages of development; thus standard protocols, and patient inclusion criteria should be established beforehand clinical trials.
Keyphrases
- clinical trial
- bone mineral density
- mesenchymal stem cells
- endothelial cells
- soft tissue
- low dose
- case report
- bone regeneration
- cell therapy
- bone marrow
- induced pluripotent stem cells
- postmenopausal women
- randomized controlled trial
- body composition
- pluripotent stem cells
- trauma patients
- combination therapy
- study protocol
- open label
- phase iii