Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Stavroula KanoniSarah E GrahamYuxuan WangIda SurakkaShweta RamdasXiang ZhuShoa L ClarkeKonain Fatima BhattiSailaja VedantamThomas W WinklerAdam E LockeEirini MarouliGreg J M ZajacKuan-Han H WuIoanna NtallaQin HuiDerek KlarinAustin T HilliardZeyuan WangChao XueGudmar ThorleifssonAnna HelgadottirDaniel F GudbjartssonHilma HolmIsleifur OlafssonMi Yeong HwangSohee HanMasato AkiyamaSaori SakaueChikashi TeraoMasahiro KanaiWei ZhouBen M BrumptonHumaira RasheedAki S HavulinnaYogasudha VeturiJennifer Allen PachecoElisabeth A RosenthalTodd LingrenQiPing FengIftikhar J KulloAkira NaritaJun TakayamaHilary C MartinKaren A HuntBhavi TrivediJeffrey HaesslerFranco GiulianiniYuki BradfordJason E MillerArchie CampbellKuang LinIona Y MillwoodAsif RasheedGeorge HindyJessica D FaulWei ZhaoDavid R WeirConstance TurmanHongyan HuangMariaelisa GraffAnanyo ChoudhuryDhriti SenguptaAnubha MahajanMichael R BrownWeihua ZhangKetian YuEllen M SchmidtAnita PanditStefan GustafssonXianyong YinJian'an LuanJing-Hua ZhaoFumihiko MatsudaHye-Mi JangKyungheon YoonCarolina Medina-GomezAchilleas PitsillidesJouke Jan HottengaAndrew R WoodYingji JiZishan GaoSimon HaworthNoha A YousriRuth E MitchellJin Fang ChaiMette AadahlAnne A BjerregaardJie YaoAni ManichaikulChii-Min HwuYi-Jen HungHelen R WarrenJulia RamirezJette Bork-JensenLine L KårhusAnuj GoelMaria Sabater-LlealRaymond NoordamPala MauroFloris MatteoAaron F McDaidPedro Marques-VidalMatthias WielscherStella TrompetNaveed SattarLine T MøllehaveMatthias MunzLingyao ZengJianfeng HuangBin YangAlaitz PovedaAzra KurbasicClaudia LaminaLukas ForerMarkus ScholzTessel E GaleslootJonathan P BradfieldSanni E RuotsalainenEWarwick DawJoseph M ZmudaJonathan S MitchellChristian FuchsbergerHenry ChristensenJennifer A BrodyMiguel Vazquez-MorenoMary F FeitosaMary K WojczynskiZhe WangMichael H PreussMassimo ManginoParaskevi ChristofidouNiek VerweijJan W BenjaminsJorgen EngmannNoah L TsaoAnurag VermaRoderick C SliekerKen Sin LoNuno R ZilhaoPhuong LeMarcus E KleberGraciela E DelgadoShaofeng HuoDaisuke D IkedaHiroyuki IhaJian YangJun LiuAyşe DemirkanHampton L LeonardJonathan MartenMirjam FrankBörge SchmidtLaura J SmythMarisa Cañadas-GarreChaolong WangMasahiro NakatochiAndrew WongNina Hutri-KähönenXueling SimRui XiaAlicia Huerta-ChagoyaJuan Carlos Fernandez-LopezValeriya LyssenkoSuraj S NongmaithemSwati BayyanaHeather M StringhamMarguerite R IrvinChristopher OldmeadowHan-Na KimSeungho RyuPaul R H J TimmersLiubov ArbeevaRajkumar DorajooLeslie A LangeGauri PrasadLaura Lorés-MottaMarc PauperJirong LongXiaohui LiElizabeth TheuschFumihiko TakeuchiCassandra N SpracklenAnu LoukolaSailalitha BollepalliSophie C WarnerYa Xing WangWen B WeiTeresa NutileDaniela RuggieroYun Ju SungShufeng ChenFangchao LiuJingyun YangKatherine A KentistouBernhard BanasGiuseppe Giovanni NardoneKarina MeidtnerLawrence F BielakJennifer A SmithPrashantha HebbarAliki-Eleni FarmakiEdith HoferMaoxuan LinMaria Pina ConcasSimona VaccargiuPeter J van der MostNiina PitkänenBrian E CadeSander W van der LaanKumaraswamy Naidu ChitralaStefan WeissAmy R BentleyAyo P DoumateyAdebowale A AdeyemoJong Young LeeEva R B PetersenAneta A NielsenHyeok Sun ChoiMaria NethanderSandra Freitag-WolfLorraine SouthamNigel W RaynerCarol A WangShih-Yi LinJun-Sing WangChristian CoutureLeo-Pekka LyytikäinenKjell NikusGabriel Cuellar-PartidaHenrik VestergaardBertha HidalgoOlga GiannakopoulouQiuyin CaiMorgan O OburaJessica van SettenXiaoyin LiJingjing LiangHua TangNatalie TerzikhanJae Hun ShinRebecca D JacksonAlexander P ReinerLisa Warsinger MartinZhengming ChenLiming LiTakahisa KawaguchiJoachim ThieryJoshua C BisLenore J LaunerHuaixing LiMike A NallsOlli T RaitakariSahoko IchiharaSarah H WildChristopher P NelsonHarry CampbellSusanne JägerToru NabikaFahd Al-MullaHarri NiinikoskiPeter S BraundIvana KolcicPeter KovacsTota GiardoglouTomohiro KatsuyaDominique de KleijnGert J de BorstEung Kweon KimHieab H H AdamsM Arfan IkramXiaofeng ZhuFolkert W AsselbergsAdriaan O KraaijeveldJoline W J BeulensXiao-Ou ShuLoukianos S RallidisOluf PedersenTorben HansenPaul MitchellAlex W HewittMika KähönenLouis PérusseClaude BouchardAnke TönjesYii-Der Ida ChenCraig E PennellTrevor A MoriWolfgang LiebAndre FrankeClaes OhlssonDan MellströmYoon Shin ChoHyejin LeeJian-Min YuanWoon-Puay KohSang Youl RheeJeong-Taek WooIris M HeidKlaus J StarkMartina E ZimmermannHenry VölzkeGeorg HomuthMichele K EvansAlan B ZondermanOzren PolasekGerard PasterkampImo E HoeferSusan RedlineKatja PahkalaAlbertine J OldehinkelHarold SniederGinevra BiinoReinhold SchmidtHelena SchmidtStefania BandinelliGeorge DedoussisThangavel Alphonse ThanarajSharon L R KardiaPatricia A PeyserNorihiro KatoMatthias B SchulzeGiorgia GirottoCarsten A BögerBettina JungPeter K JoshiDavid A BennettPhilip L De JagerXiangfeng LuVasiliki MamakouMorris BrownMark J CaulfieldPatricia B MunroeXiuqing GuoMarina CiulloJost B JonasNilesh J SamaniJaakko KaprioPäivi PajukantaTeresa Tusié-LunaCarlos A Aguilar-SalinasLinda S AdairSonny Augustin BechaydaH Janaka de SilvaAnanda R WickremasingheRonald M KraussJer-Yuarn WuWei ZhengAnneke Iden HollanderDwaipayan BharadwajAdolfo CorreaJames G WilsonLars LindChew-Kiat HengAmanda E NelsonYvonne M GolightlyJames F WilsonBrenda PenninxHyung-Lae KimJohn AttiaRodney J ScottD C RaoDonna K ArnettSteven C HuntMark WalkerHeikki A KoistinenGiriraj R ChandakJosep M MercaderMaria C CostanzoDongkeun JangNoël P BurttClicerio Gonzalez VillalpandoLorena OrozcoMyriam FornageEShyong TaiRob M van DamTerho LehtimäkiNish ChaturvediMitsuhiro YokotaJianjun LiuDermot F ReillyAmy Jayne McKnightFrank KeeKarl-Heinz JöckelMark I McCarthyColin N A PalmerVeronique VitartCaroline HaywardEleanor SimonsickCornelia M van DuijnZi-Bing JinJia QuHaretsugu HishigakiXu LinWinfried MärzVilmundur GudnasonJean-Claude TardifGuillaume LettreLeen M 't HartPetra J M EldersScott M DamrauerMeena KumariMika KivimakiPim van der HarstTim D SpectorRuth J F LoosMichael A ProvinceEsteban J ParraMiguel CruzBruce M PsatyIvan BrandslundPeter P PramstallerCharles N RotimiKaare ChristensenSamuli RipattiElisabeth WidénHakon HakonarsonStruan F A GrantLambertus A L M KiemeneyJacqueline de GraafMarkus LoefflerFlorian KronenbergDongfeng GuJeanette ErdmannHeribert SchunkertPaul W FranksAllan LinnebergJ Wouter JukemaAmit V KheraMinna MännikköMarjo-Riitta JarvelinZoltan KutalikCucca FrancescoDennis O Mook-KanamoriKo Willems van DijkHugh WatkinsDavid P StrachanNiels GrarupPeter SeverNeil PoulterLee-Ming ChuangJerome I RotterThomas M DantoftFredrik KarpeMatt J NevilleNicholas J TimpsonChing-Yu ChengTien-Yin WongChiea Chuen KhorHengtong LiCharumathi SabanayagamAnnette PetersChristian GiegerAndrew T HattersleyNancy L PedersenPatrik K E MagnussonDorret I BoomsmaAllegonda H M WillemsenLAdrienne CupplesJoyce B J van MeursMohsen GhanbariPenny Gordon-LarsenWei HuangYoung Jin KimYasuharu TabaraNicholas J WarehamClaudia LangenbergEleftheria ZegginiJohanna KuusistoMarkku LaaksoErik IngelssonGoncalo AbecasisJohn C ChambersJaspal S KoonerPaul S de VriesAlanna C MorrisonScott HazelhurstMichèle RamsayKari E NorthMartha DaviglusPeter KraftNicholas G MartinJohn B WhitfieldShahid AbbasDanish SaleheenRobin G WaltersMichael V HolmesCorri BlackBlair H SmithAris BarasAnne E JusticeJulie E BuringPaul M RidkerDaniel I ChasmanCharles KooperbergGen TamiyaMasayuki YamamotoDavid A van HeelRichard C TrembathWei-Qi WeiGail P JarvikBahram NamjouM Geoffrey HayesMarylyn D RitchiePekka JousilahtiVeikko SalomaaKristian HveemBjørn Olav ÅsvoldMichiaki KuboYoichiro KamataniYukinori OkadaYoshinori MurakamiBong-Jo KimUnnur ThorsteinsdottirKari StefanssonJifeng ZhangYEugene ChenYuk-Lam HoJulie A LynchDaniel J RaderPhilip S TsaoKyong-Mi ChangKelly ChoChristopher J O'DonnellJohn M GazianoPeter W F WilsonTimothy M FraylingJoel N HirschhornSekar KathiresanKaren L MohlkeYan V SunAndrew P MorrisMichael BoehnkeChristopher D BrownPradeep NatarajanPanos DeloukasCristen J WillerThemistocles L AssimesGina M PelosoPublished in: Genome biology (2022)
Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.