Cooperative armoring of CAR and TCR T-cells by T cell-restricted IL-15 and IL-21 universally enhances solid tumor efficacy.
Rosa NguyenEkaterina DoubrovinaCharlotte M MoussetBenjamin Y JinReona OkadaXiyuan ZhangArina ClavelJeyshka M Reyes-GonzálezVadim DyominLouis DiazLing ZhangShahroze AbbasMing SunChao-Ming HsiehMitchell HoJack F ShernJames L GulleyChristian S HinrichsPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
The co-expression of membrane-tethered IL-15 and IL-21 represents a technology to enhance the resilience and function of engineered T-cells against solid tumors and could be applicable to multiple therapy platforms and diseases.