Effect of age and sex on immune checkpoint expression and kinetics in human T cells.
Rosanne D ReitsemaRebeca Hid CadenaSander H NijhofWayel H AbdulahadMinke G HuitemaDavy PaapElisabeth BrouwerAnnemieke M H BootsPeter HeeringaPublished in: Immunity & ageing : I & A (2020)
Collectively, our results demonstrate that both age and sex modulate expression of immune checkpoints by human T cells. These findings may have implications for optimising vaccination and immune checkpoint immunotherapy and move the field towards precision medicine in the management of older patient groups.