IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.
Alexandra Coomans de BrachèneReinaldo S Dos SantosLaura MarroquiMaikel L ColliLorella MarselliRaghavendra G MirmiraPiero MarchettiDecio L EizirikPublished in: Diabetologia (2018)
IFN-α mediates a long-lasting and preferential MHC class I overexpression in human beta cells, which is not affected by the subsequent addition of JAK inhibitors. These observations suggest that IFN-α-stimulated long-lasting MHC class I expression may amplify beta cell antigen presentation during the early phase of type 1 diabetes and that IFN-α inhibitors might need to be used at very early stages of the disease to be effective.
Keyphrases
- induced apoptosis
- dendritic cells
- immune response
- endothelial cells
- poor prognosis
- cell cycle arrest
- induced pluripotent stem cells
- endoplasmic reticulum stress
- signaling pathway
- single cell
- pluripotent stem cells
- binding protein
- long non coding rna
- cell death
- transcription factor
- mesenchymal stem cells
- stem cells
- oxidative stress
- bone marrow