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IFN-α induces a preferential long-lasting expression of MHC class I in human pancreatic beta cells.

Alexandra Coomans de BrachèneReinaldo S Dos SantosLaura MarroquiMaikel L ColliLorella MarselliRaghavendra G MirmiraPiero MarchettiDecio L Eizirik
Published in: Diabetologia (2018)
IFN-α mediates a long-lasting and preferential MHC class I overexpression in human beta cells, which is not affected by the subsequent addition of JAK inhibitors. These observations suggest that IFN-α-stimulated long-lasting MHC class I expression may amplify beta cell antigen presentation during the early phase of type 1 diabetes and that IFN-α inhibitors might need to be used at very early stages of the disease to be effective.
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