Clinical Intervention to Reduce Dietary Sugar Does Not Affect Liver Fat in Latino Youth, Regardless of PNPLA3 Genotype: A Randomized Controlled Trial.
Kelsey A SchmidtRoshonda B JonesClaudia RiosYesica CoronaPaige K BergerJasmine F PlowsTanya L AldereteJennifer FogelHailey HampsonJaana A HartialaZhiheng CaiHooman AllayeeKrishna S NayakFrank R SinatraGregory HarlanTrevor A PickeringSarah-Jeanne SalvyWendy Jean MackRohit KohliMichael I GoranPublished in: The Journal of nutrition (2022)
In Latino youth with obesity, a dietitian-led sugar reduction intervention did not improve liver outcomes compared with control, regardless of PNPLA3 genotype. Results suggest FM reduction is important for liver fat reduction, confirming clinical recommendations of weight loss and a healthy diet for pediatric NAFLD.This trial was registered at clinicaltrials.gov as NCT02948647.
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