Iron Reduces the Trafficking of Fatty Acids from Human Immortalised Brain Microvascular Endothelial Cells Through Modulation of Fatty Acid Transport Protein 1 (FATP1/SLC27A1).
Showmika T SuptiLiam M KoehnStephanie A NewmanYijun PanJoseph A NicolazzoPublished in: Pharmaceutical research (2024)
These studies demonstrate a role of iron in down-regulating FATP1 protein abundance and function at the BBB, which may have implications on fatty acid access to the brain.
Keyphrases
- fatty acid
- endothelial cells
- resting state
- white matter
- protein protein
- amino acid
- blood brain barrier
- high glucose
- cerebral ischemia
- iron deficiency
- binding protein
- small molecule
- vascular endothelial growth factor
- induced pluripotent stem cells
- case control
- pluripotent stem cells
- antibiotic resistance genes
- wastewater treatment