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Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis .

Alexander SturmPenny SunJulian Avila-PachecoAnne E ClatworthyZohar Bloom-AckermannMichael G WuoJames E GomezSoomin JinClary B ClishLaura L KiesslingDeborah T Hung
Published in: mBio (2024)
, is involved in storing and utilizing fatty acids as bacteria transition between these two states. Importantly, inhibiting lipid metabolism using a lipase inhibitor eradicates non-growing bacteria. Thus, targeting lipid metabolism may be a viable strategy for treating the non-growing population in strategies to shorten treatment durations of tuberculosis.
Keyphrases
  • fatty acid
  • mycobacterium tuberculosis
  • pulmonary tuberculosis
  • signaling pathway
  • emergency department
  • cancer therapy
  • combination therapy
  • replacement therapy