Genetic factors affecting storage and utilization of lipids during dormancy in Mycobacterium tuberculosis .
Alexander SturmPenny SunJulian Avila-PachecoAnne E ClatworthyZohar Bloom-AckermannMichael G WuoJames E GomezSoomin JinClary B ClishLaura L KiesslingDeborah T HungPublished in: mBio (2024)
, is involved in storing and utilizing fatty acids as bacteria transition between these two states. Importantly, inhibiting lipid metabolism using a lipase inhibitor eradicates non-growing bacteria. Thus, targeting lipid metabolism may be a viable strategy for treating the non-growing population in strategies to shorten treatment durations of tuberculosis.