Endothelial CCRL2 induced by disturbed flow promotes atherosclerosis via chemerin-dependent β2 integrin activation in monocytes.

Chaojun TangGuona ChenFan WuYiren CaoFei YangTao YouChu LiuMenglu LiShuhong HuLijie RenQiongyu LuWei DengYing XuGuixue WangHanjoong JoYonghong ZhangYi WuBrian A ZabelLi Zhu

Published in: Cardiovascular research (2023)

Our findings indicate that d-flow-induced CCRL2 promotes atherosclerotic plaque formation via a novel CCRL2-chemerin-β2 integrin axis, providing potential targets for the prevention or therapeutic intervention of atherosclerosis.

Keyphrases

cardiovascular disease
randomized controlled trial
high glucose
endothelial cells
coronary artery disease
cell adhesion
diabetic rats
type diabetes
dendritic cells
oxidative stress
risk assessment